How sensitive and accurate are routine NMR and MS measurements?

被引：112

作者：

Tsedilin, Andrey M. ^{[1
]}

Fakhrutdinov, Artem N. ^{[1
]}

Eremin, Dmitry B. ^{[1
]}

Zalesskiy, Sergey S. ^{[1
]}

Chizhov, Alexander O. ^{[1
]}

Kolotyrkina, Natalya G. ^{[1
]}

Ananikov, Valentine P. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia

来源：

MENDELEEV COMMUNICATIONS | 2015年 / 25卷 / 06期

基金：

俄罗斯科学基金会;

关键词：

NUCLEAR-MAGNETIC-RESONANCE; NANOMECHANICAL MASS-SPECTROMETRY; ELECTROSPRAY-IONIZATION; SPECTROSCOPY; CHEMISTRY; INSIGHT; SYSTEMS; LIQUID;

D O I：

10.1016/j.mencom.2015.11.019

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The necessary prerequisites to carry out efficient NMR/MS studies and the important points required to avoid inconsistent measurements are discussed. A comparative assessment of the sensitivity and accuracy of NMR, EI-MS and ESI-MS measurements was carried out to evaluate typical laboratory research performance. Accurate NMR measurements are possible in the 10(-1)-10(-3) M concentration range, with spectral studies still being possible at concentrations of approximately 10(-4)-10(-5) M. ELMS is more sensitive and can operate at concentrations of 10(-6) M, while commonly available ESI-MS can be efficient up to a concentration of 10(-18) M.

引用

页码：454 / 456

页数：3

共 38 条

[1] Insight into Solution Chemistry from Gas-Phase Experiments [J].

Agrawal, Divya ;

Schroeder, Detlef .

ORGANOMETALLICS, 2011, 30 (01) :32-35

[2]

Albert K., 2002, On-Line LC-NMR and Related Techniques

[3] Development of new methods in modern selective organic synthesis: preparation of functionalized molecules with atomic precision [J].

Ananikov, V. P. ;

Khemchyan, L. L. ;

Ivanova, Yu V. ;

Bukhtiyarov, V. I. ;

Sorokin, A. M. ;

Prosvirin, I. P. ;

Vatsadze, S. Z. ;

Medved'ko, A. V. ;

Nuriev, V. N. ;

Dilman, A. D. ;

Levin, V. V. ;

Koptyug, I. V. ;

Kovtunov, K. V. ;

Zhivonitko, V. V. ;

Likholobov, V. A. ;

Romanenko, A. V. ;

Simonov, P. A. ;

Nenajdenko, V. G. ;

Shmatova, I. ;

Muzalevskiy, V. M. ;

Nechaev, M. S. ;

Asachenko, A. F. ;

Morozov, S. ;

Dzhevakov, P. B. ;

Osipov, S. N. ;

Vorobyeva, D. V. ;

Topchiy, M. A. ;

Zotova, M. A. ;

Ponomarenko, S. A. ;

Borshchev, V. ;

Luponosov, Yu N. ;

Rempel, A. A. ;

Valeeva, A. A. ;

Stakheev, A. Yu. ;

Turov, V. ;

Mashkovsky, I. S. ;

Sysolyatin, S. V. ;

Malykhin, V. V. ;

Bukhtiyarova, G. A. ;

Terent'ev, A. O. ;

Krylov, I. B. .

RUSSIAN CHEMICAL REVIEWS, 2014, 83 (10) :885-985

[4]

Bax A., 1982, 2 DIMENSIONAL NMR LI

[5] Mechanistic insight into organic and catalytic reactions by joint studies using mass spectrometry and NMR spectroscopy [J].

Belyakov, Pavel A. ;

Kadentsev, Valentine I. ;

Chizhov, Alexander O. ;

Kolotyrkina, Natal'ya G. ;

Shashkov, Alexander S. ;

Ananikov, Valentine P. .

MENDELEEV COMMUNICATIONS, 2010, 20 (03) :125-131

[6]

Eelman M. D., 2008, ANGEW CHEM, V120, P309

[7]

Elippe M. V. Silva, 2003, ANAL CHIM ACTA, V1, P497

[8]

Ernst R.R., 1987, Principles of NMR in one and two dimensions

[9] ELECTROSPRAY IONIZATION FOR MASS-SPECTROMETRY OF LARGE BIOMOLECULES [J].

FENN, JB ;

MANN, M ;

MENG, CK ;

WONG, SF ;

WHITEHOUSE, CM .

SCIENCE, 1989, 246 (4926) :64-71

[10] Electrospray wings for molecular elephants (Nobel lecture) [J].

Fenn, JB .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (33) :3871-3894

← 1 2 3 4 →