Traceless, solid-phase synthesis of biarylmethane structures through Pd-catalyzed release of supported benzylsulfonium salts

被引：1

作者：

Vanier, C ^{[1
]}

Lorgé, F ^{[1
]}

Wagner, A ^{[1
]}

Mioskowski, C ^{[1
]}

机构：

[1] Univ Louis Pasteur Strasbourg 1, Lab Synth Bioorgan, Fac Pharm, CNRS,UMR 7514, F-67401 Illkirch Graffenstaden, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2000年 / 39卷 / 09期

关键词：

cleavage reactions; cross-coupling; solid-phase synthesis; sulfides; synthetic methods;

D O I：

10.1002/(SICI)1521-3773(20000502)39:9<1679::AID-ANIE1679>3.0.CO;2-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new safety-catch linker for the solid-phase synthesis (SPS) of biarylmethane structures (see scheme) has been identified from a study of the reactivity of acyclic sulfonium salts towards a Pd-catalyzed cross-coupling reaction. The sulfide link is compatible with most SPS reaction conditions and hence this novel anchoring/activation/release sequence should enable many libraries to be synthesized by solid-phase synthesis.

引用

页码：1679 / +

页数：6

共 44 条

[1] Activation method to prepare a highly reactive acylsulfonamide ''safety-catch'' linker for solid-phase synthesis [J].