Hemoglobin-based oxygen carriers

被引：32
作者：
Stowell, CP
机构：
[1] Massachusetts Gen Hosp, Blood Transfus Serv, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02215 USA
来源：
CURRENT OPINION IN HEMATOLOGY | 2002年 / 9卷 / 06期
关键词：
D O I：
10.1097/00062752-200211000-00013
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Three types of materials have been studied as candidate blood substitutes: the perfluorocarbons, modified hemoglobins, and liposome-encapsulated hemoglobin. Progress has been greatest with the hemoglobin-based oxygen carriers. Hemoglobin is a highly active molecule; hence, modification has been required to avoid potential deleterious effects. Although there has been considerable progress toward bringing such a product to the clinic, its development has challenged understanding of oxygen delivery and use. The study of these molecules has provided new insights into basic physiologic processes. (C) 2002 Lippincott Williams Wilkins, Inc.
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收藏
页码：537 / 543
页数：7
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