Light chain deposition disease and proximal tubulopathy in two successive kidney allografts

被引：7

作者：

Drieux, Fanny ^{[1
,2
]}

Loron, Marie-Charlotte ^{[1
,2
]}

Francois, Arnaud ^{[2
]}

Bertrand, Dominique ^{[1
]}

Etienne, Isabelle ^{[1
]}

Bender, Sebastien ^{[3
,4
]}

Godin, Michel ^{[1
,5
]}

Guerrot, Dominique ^{[1
,5
]}

机构：

[1] Rouen Univ Hosp, Nephrol Dept, 1 Rue Germont, F-76031 Rouen, France

[2] Rouen Univ Hosp, Pathol Dept, Rouen, France

[3] Limoges Med Univ, CNRS UMR 7276, Rouen, France

[4] Limoges Med Univ, Ctr Reference Amyloses Primit & Autres Malad Depo, Rouen, France

[5] Rouen Med Univ, INSERM U1096, Rouen, France

来源：

CLINICAL NEPHROLOGY | 2015年 / 83卷 / 06期

关键词：

light chain deposition disease; light chain proximal tubulopathy; recurrence; kidney allograft; myeloma; FANCONI-SYNDROME; MYELOMA; TRANSPLANTATION; NEPHROPATHY; SPECTRUM; INJURY;

D O I：

10.5414/CN108319

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Light chain proximal tubu-lo-pathy (LCPT) is a rare kidney disease associated with plasma cell dyscrasias, characterized by light chain deposits in the proximal tubular cells, with or without crystal formation. We describe an exceptional case of LCPT without crystal formation in a kidney allograft, in a patient who underwent two renal transplants for a light chain deposition disease (LCDD) complicating smoldering myeloma. This is the first description of this association in successive kidney allografts. We concisely describe pathology of LCDD and LCPT and discuss potential pathophysiological mechanisms relating these two conditions.

引用

页码：351 / 356

页数：6

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