Source Apportionment of Fine-Particle, Water-Soluble Organic Nitrogen and Its Association with the Inflammatory Potential of Lung Epithelial Cells

被引:39
作者
Liu, Qingyang [1 ,2 ]
Baumgartner, Jill [3 ,4 ]
Schauer, James J. [5 ,6 ]
机构
[1] Nanjing Forestry Univ, Coll Biol & Environm, Coinnovat Ctr Sustainable Forestry Southern China, Nanjing 210037, Jiangsu, Peoples R China
[2] Beijing Ctr Phys & Chem Anal, Beijing 100089, Peoples R China
[3] McGill Univ, Inst Hlth & Social Policy, Montreal, PQ H3A 0G4, Canada
[4] McGill Univ, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ H3A 1A3, Canada
[5] Univ Wisconsin, Environm Chem & Technol Program, Madison, WI 53706 USA
[6] Univ Wisconsin, Wisconsin State Lab Hyg, Madison, WI 53718 USA
基金
美国国家科学基金会;
关键词
POSITIVE MATRIX FACTORIZATION; ON-ROAD VEHICLES; PARTICULATE MATTER; AIR-POLLUTION; CHEMICAL-CHARACTERIZATION; SYSTEMIC INFLAMMATION; SEASONAL-VARIATION; SOURCE PROFILES; NORTHERN CHINA; TNF-ALPHA;
D O I
10.1021/acs.est.9b02523
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Identifying the key chemical compounds and source contributions in ambient particles associated with the burden of cardiopulmonary disease is important to develop cost-effective air pollution mitigating strategies that maximize the protection of public health. To help address this need, we examined 109 daily ambient fine particulate matter samples (PM2.5) that were collected in Beijing in one year. The samples were analyzed for chemical composition including organic and elemental carbons, metals, ions, as well as organic molecular markers. In addition, the secretion of pro-inflammatory cytokines, tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) were measured by exposing lung epithelial cells (A549) to water extracts of PM2.5 samples. Single pollutant and constituent-PM25 joint linear models were used to estimate the associations. Higher PM2.5 mass and measured chemical components were found in cold seasons than in warm seasons due to the greater contributions of secondary inorganic sources, biomass burning, and coal combustion. Water-soluble organic nitrogen (WSON) had the strongest associations with levels of pro-inflammatory cytokines compared to PM2.5 mass and other chemical species in both the one and constituent-PM25 joint linear models. Our study is the first to highlight that ambient WSON from diverse sources dominates the inflammatory potential of lung epithelial cells.
引用
收藏
页码:9845 / 9854
页数:10
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