The impact of obesity on skin disease and epidermal permeability barrier status

被引:57
作者
Guida, B. [1 ]
Nino, M. [2 ]
Perrino, N. R. [2 ]
Laccetti, R. [2 ]
Trio, R. [2 ]
Labella, S. [2 ]
Balato, N. [2 ]
机构
[1] Univ Naples Federico II, Dept Neurosci, Physiol Nutr Unit, Naples, Italy
[2] Univ Naples Federico II, Dept Dermatol, Naples, Italy
关键词
dermatoses; obesity; transepidermal water loss; TRANSEPIDERMAL WATER-LOSS; BIOELECTRICAL-IMPEDANCE ANALYSIS; INSULIN-RESISTANCE; ADIPOSE-TISSUE; BODY-MASS; COLLAGEN; SUSCEPTIBILITY; INFLAMMATION; PREVALENCE; VALIDATION;
D O I
10.1111/j.1468-3083.2009.03503.x
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background Obese subjects frequently show skin diseases. However, less attention has been paid to the impact of obesity on skin disorders until now. Objective The purposes of this study are: to highlight the incidence of some dermatoses in obese subjects and to study the water barrier function of the obese skin using transepidermal water loss (TEWL). Methods Sixty obese subjects and 20 normal weight volunteers were recruited. Obese group was further divided into three body mass index (BMI) classes: class I (BMI 30-34.9 kg/m2), class II (BMI 35-39.9 kg/m2) and class III (BMI 40 g/m2). All subjects attended dermatological examination for skin diseases. To assess barrier function, TEWL measurements were performed on the volar surface of the forearm using a tewameter. Results The results of this study showed that: (i) obese subjects show a higher incidence of some dermatoses compared with normal-weight controls; in addition the dermatoses are more, frequent as BMI increases; (ii) the rate of TEWL is lower in obese subjects, than in the normal-weight subjects, particularly in patients with intra-abdominal obesity. Conclusion Specific dermatoses as skin tags, striae distensae and plantar hyperkeratosis, could be considered as a cutaneous stigma of severe obesity. The low permeability of the skin to evaporative water loss is observed in obese subjects compared with normal weight control. Although the physiological mechanisms are still unknown, this finding has not been previously described and we believe that this may constitute a new field in the research on obesity.
引用
收藏
页码:191 / 195
页数:5
相关论文
共 34 条
[1]  
Aggarwal BB, 2006, E SCHERING RES FDN W, V56, P161
[2]  
[Anonymous], 2020, WHO Technical Report Series 1004, Annex 9, 2017: World Health Organization
[3]   Prevalence of obesity in the United States [J].
Baskin, ML ;
Ard, J ;
Franklin, F ;
Allison, DB .
OBESITY REVIEWS, 2005, 6 (01) :5-7
[4]   Expression of TWEAK and its receptor Fn14 in human subcutaneous adipose tissue.: Relationship with other inflammatory cytokines in obesity [J].
Chacón, MR ;
Richart, C ;
Gómez, JM ;
Megía, A ;
Vilarrasa, N ;
Fernández-Real, JM ;
García-España, A ;
Miranda, M ;
Masdevall, C ;
Ricard, W ;
Caubet, E ;
Soler, J ;
Vendrell, J .
CYTOKINE, 2006, 33 (03) :129-137
[5]  
CHALDAKOV GN, 2006, NUTR HLTH ADIPOSE TI, P147
[6]  
DARLENSKI R, 2008, EUR J PHARM BIOPHARM
[7]   Stratum corneum cytokines and skin irritation response to sodium lauryl sulfate [J].
De Jongh, CM ;
Verberk, MM ;
Withagen, CET ;
Jacobs, JJL ;
Rustemeyer, T ;
Kezic, S .
CONTACT DERMATITIS, 2006, 54 (06) :325-333
[8]   INSULIN RESISTANCE - A MULTIFACETED SYNDROME RESPONSIBLE FOR NIDDM, OBESITY, HYPERTENSION, DYSLIPIDEMIA, AND ATHEROSCLEROTIC CARDIOVASCULAR-DISEASE [J].
DEFRONZO, RA ;
FERRANNINI, E .
DIABETES CARE, 1991, 14 (03) :173-194
[9]  
ENSER M, 1984, DIABETOLOGIA, V27, P44
[10]   Transepidermal water loss reflects permeability barrier status:: validation in human and rodent in vivo and ex vivo models [J].
Fluhr, Joachim W. ;
Feingold, Kenneth R. ;
Elias, Peter M. .
EXPERIMENTAL DERMATOLOGY, 2006, 15 (07) :483-492