Regeneration Profiles of Olfactory Epithelium after SARS-CoV-2 Infection in Golden Syrian Hamsters

被引：31
作者：
Urata, Shinji [1 ,2 ]
Maruyama, Junki [3 ]
Kishimoto-Urata, Megumi [2 ,3 ]
Sattler, Rachel A. [3 ]
Cook, Rebecca [1 ]
Lin, Nantian [1 ]
Yamasoba, Tatsuya [2 ]
Makishima, Tomoko [1 ]
Paessler, Slobodan [3 ]
机构：
[1] Univ Texas Med Branch, Dept Otolaryngol, Galveston, TX 77555 USA
[2] Univ Tokyo, Grad Sch Med, Dept Otolaryngol, Tokyo 1130033, Japan
[3] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA
来源：
ACS CHEMICAL NEUROSCIENCE | 2021年 / 12卷 / 04期
基金：
美国国家卫生研究院;
关键词：
COVID-19; SARS-CoV-2; olfactory epithelium; olfactory dysfunction; anosmia;
D O I：
10.1021/acschemneuro.0c00649
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Olfactory dysfunction is one of the most frequent and specific symptoms of coronavirus disease 2019 (COVID-19). Information on the damage and repair of the neuroepithelium and its impact on olfactory function after COVID-19 is still incomplete. While severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the ongoing worldwide outbreak of COVID-19, little is known about the changes triggered by SARS-CoV-2 in the olfactory epithelium (OE) at the cellular level. Here, we report profiles of the OE after SARS-CoV-2 infection in golden Syrian hamsters, which is a reliable animal model of COVID-19. We observed severe damage in the OE as early as 3 days postinoculation and regionally specific damage and regeneration of the OE within the nasal cavity; the nasal septal region demonstrated the fastest recovery compared to other regions in the nasal turbinates. These findings suggest that anosmia related to SARS-CoV-2 infection may be fully reversible.
引用
收藏
页码：589 / 595
页数：7
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