Regeneration Profiles of Olfactory Epithelium after SARS-CoV-2 Infection in Golden Syrian Hamsters

被引：31
作者：
Urata, Shinji [1 ,2 ]
Maruyama, Junki [3 ]
Kishimoto-Urata, Megumi [2 ,3 ]
Sattler, Rachel A. [3 ]
Cook, Rebecca [1 ]
Lin, Nantian [1 ]
Yamasoba, Tatsuya [2 ]
Makishima, Tomoko [1 ]
Paessler, Slobodan [3 ]
机构：
[1] Univ Texas Med Branch, Dept Otolaryngol, Galveston, TX 77555 USA
[2] Univ Tokyo, Grad Sch Med, Dept Otolaryngol, Tokyo 1130033, Japan
[3] Univ Texas Med Branch, Dept Pathol, Galveston, TX 77555 USA
来源：
ACS CHEMICAL NEUROSCIENCE | 2021年 / 12卷 / 04期
基金：
美国国家卫生研究院;
关键词：
COVID-19; SARS-CoV-2; olfactory epithelium; olfactory dysfunction; anosmia;
D O I：
10.1021/acschemneuro.0c00649
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Olfactory dysfunction is one of the most frequent and specific symptoms of coronavirus disease 2019 (COVID-19). Information on the damage and repair of the neuroepithelium and its impact on olfactory function after COVID-19 is still incomplete. While severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the ongoing worldwide outbreak of COVID-19, little is known about the changes triggered by SARS-CoV-2 in the olfactory epithelium (OE) at the cellular level. Here, we report profiles of the OE after SARS-CoV-2 infection in golden Syrian hamsters, which is a reliable animal model of COVID-19. We observed severe damage in the OE as early as 3 days postinoculation and regionally specific damage and regeneration of the OE within the nasal cavity; the nasal septal region demonstrated the fastest recovery compared to other regions in the nasal turbinates. These findings suggest that anosmia related to SARS-CoV-2 infection may be fully reversible.
引用
收藏
页码：589 / 595
页数：7
相关论文
共 50 条
  • [1] The Microvillar and Solitary Chemosensory Cells as the Novel Targets of Infection of SARS-CoV-2 in Syrian Golden Hamsters
    Seo, Jin-Seok
    Yoon, Sun-Woo
    Hwang, Seung-Hyeon
    Nam, Sung-Min
    Nahm, Sang-Soep
    Jeong, Jei-Hyun
    Lee, Jiho
    Youn, Ha-Na
    Kim, Jun-Beom
    Kim, Woosuk
    VIRUSES-BASEL, 2021, 13 (08):
  • [2] SARS-CoV-2 infection induces persistent adipose tissue damage in aged golden Syrian hamsters
    Bogard, Gemma
    Barthelemy, Johanna
    Hantute-Ghesquier, Aline
    Sencio, Valentin
    Brito-Rodrigues, Patricia
    Seron, Karin
    Robil, Cyril
    Flourens, Anne
    Pinet, Florence
    Eberle, Delphine
    Trottein, Francois
    Duterque-Coquillaud, Martine
    Wolowczuk, Isabelle
    CELL DEATH & DISEASE, 2023, 14 (02)
  • [3] Golden Syrian Hamsters as a Model for Revisiting the Role of Biological Sex Differences in SARS-CoV-2 Infection
    Michita, Rafael Tomoya
    Mysorekar, Indira U.
    MBIO, 2021, 12 (06):
  • [4] Diet-induced obesity and NASH aggravate SARS-CoV-2 infection in golden Syrian hamsters
    Briand, Francois
    Sencio, Valentin
    Sulpice, Thierry
    Trottein, Francois
    METABOLISM-CLINICAL AND EXPERIMENTAL, 2022, 128 : S18 - S18
  • [5] Neutrophils play a major role in the destruction of the olfactory epithelium during SARS-CoV-2 infection in hamsters
    Bourgon, Clara
    Albin, Audrey St
    Ando-Grard, Ophelie
    Da Costa, Bruno
    Domain, Roxane
    Korkmaz, Brice
    Klonjkowski, Bernard
    Le Poder, Sophie
    Meunier, Nicolas
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2022, 79 (12)
  • [6] Vasculitis and Neutrophil Extracellular Traps in Lungs of Golden Syrian Hamsters With SARS-CoV-2
    Becker, Kathrin
    Beythien, Georg
    de Buhr, Nicole
    Stanelle-Bertram, Stephanie
    Tuku, Berfin
    Kouassi, Nancy Mounogou
    Beck, Sebastian
    Zickler, Martin
    Allnoch, Lisa
    Gabriel, Gulsah
    Von Kockritz-Blickwede, Maren
    Baumgaertner, Wolfgang
    FRONTIERS IN IMMUNOLOGY, 2021, 12
  • [7] Oral SARS-CoV-2 Inoculation Establishes Subclinical Respiratory Infection with Virus Shedding in Golden Syrian Hamsters
    Lee, Andrew Chak-Yiu
    Zhang, Anna Jinxia
    Chan, Jasper Fuk-Woo
    Li, Can
    Fan, Zhimeng
    Liu, Feifei
    Chen, Yanxia
    Liang, Ronghui
    Sridhar, Siddharth
    Cai, Jian-Piao
    Poon, Vincent Kwok-Man
    Chan, Chris Chung-Sing
    To, Kelvin Kai-Wang
    Yuan, Shuofeng
    Zhou, Jie
    Chu, Hin
    Yuen, Kwok-Yung
    CELL REPORTS MEDICINE, 2020, 1 (07)
  • [8] Age-Dependent Progression of SARS-CoV-2 Infection in Syrian Hamsters
    Osterrieder, Nikolaus
    Bertzbach, Luca D.
    Dietert, Kristina
    Abdelgawad, Azza
    Vladimirova, Daria
    Kunec, Dusan
    Hoffmann, Donata
    Beer, Martin
    Gruber, Achim D.
    Trimpert, Jakob
    VIRUSES-BASEL, 2020, 12 (07):
  • [9] A biomathematical model of SARS-CoV-2 in Syrian hamsters
    Schirm, Sibylle
    Nouailles, Geraldine
    Kirsten, Holger
    Trimpert, Jakob
    Wyler, Emanuel
    Alves, Luiz Gustavo Teixeira
    Landthaler, Markus
    Ahnert, Peter
    Suttorp, Norbert
    Witzenrath, Martin
    Scholz, Markus
    SCIENTIFIC REPORTS, 2024, 14 (01):
  • [10] Differential immunometabolic responses to Delta and Omicron SARS-CoV-2 variants in golden syrian hamsters
    Rajaiah, Rajesh
    Pandey, Kabita
    Acharya, Arpan
    Ambikan, Anoop
    Kumar, Narendra
    Guda, Reema
    Avedissian, Sean N.
    Montaner, Luis J.
    Cohen, Samuel M.
    Neogi, Ujjwal
    Byrareddy, Siddappa N.
    ISCIENCE, 2024, 27 (08)
12345