CYP2C19*2 polymorphism is not the sole determinant of the response to clopidogrel: implications for its monitoring

被引：23
作者：
Aleil, B. [1 ,2 ]
Leon, C. [1 ]
Cazenave, J. -P. [1 ]
Gachet, C. [1 ]
机构：
[1] Univ Strasbourg, INSERM, UMR SU949, EFS Alsace, F-67065 Strasbourg, France
[2] Clin Orangerie, Serv Cardiol, Strasbourg, France
来源：
JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2009年 / 7卷 / 10期
关键词：
CARDIOVASCULAR EVENTS; PLATELET REACTIVITY; RESISTANCE; PHARMACOKINETICS; RESPONSIVENESS; VARIABILITY; PRASUGREL;
D O I：
10.1111/j.1538-7836.2009.03554.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：1747 / 1749
页数：3
相关论文
共 17 条
  • [1] Clopidogrel 150 mg/day to Overcome Low Responsiveness in Patients Undergoing Elective Percutaneous Coronary Intervention Results From the VASP-02 (Vasodilator-Stimulated Phosphoprotein-02) Randomized Study
    Aleil, Boris
    Jacquemin, Laurent
    De Poli, Fabien
    Zaehringer, Michel
    Collet, Jean-Philippe
    Montalescot, Gilles
    Cazenave, Jean-Pierre
    Dickele, Marie-Claude
    Monassier, Jean-Pierre
    Gachet, Christian
    [J]. JACC-CARDIOVASCULAR INTERVENTIONS, 2008, 1 (06) : 631 - 638
  • [2] Contribution of gene sequence variations of the hepatic cytochrome P450 3A4 enzyme to variability in individual responsiveness to clopidogrel
    Angiolillo, Dominick J.
    Fernandez-Ortiz, Antonio
    Bernardo, Esther
    Ramirez, Celia
    Cavallari, Ugo
    Trabetti, Elisabetta
    Sabate, Manel
    Hernandez, Rosana
    Moreno, Raul
    Escaned, Javier
    Alfonso, Fernando
    Banuelos, Camino
    Costa, Marco A.
    Bass, Theodore A.
    Pignatti, Pier Franco
    Macaya, Carlos
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (08) : 1895 - 1900
  • [3] Adjusted clopidogrel loading doses according to vasodilator-stimulated phosphoprotein phosphorylation index decrease rate of major adverse cardiovascular events in patients with clopidogrel resistance: A multicenter randomized prospective study
    Bonello, Laurent
    Camoin-Jau, Laurence
    Arques, Stephane
    Boyer, Christian
    Panagides, Dimitri
    Wittenberg, Olivier
    Simeoni, Marie-Claude
    Barragan, Paul
    Dignat-George, Francoise
    Paganelli, Franck
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 51 (14) : 1404 - 1411
  • [4] Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study
    Collet, Jean-Philippe
    Hulot, Jean-Sebastien
    Pena, Anna
    Villard, Eric
    Esteve, Jean-Baptiste
    Silvain, Johanne
    Payot, Laurent
    Brugier, Delphine
    Cayla, Guillaume
    Beygui, Farzin
    Bensimon, Gilbert
    Funck-Brentano, Christian
    Montalescot, Gilles
    [J]. LANCET, 2009, 373 (9660) : 309 - 317
  • [5] Clopidogrel resistance: Role of body mass and concomitant medications
    Feher, Gergely
    Koltai, Katalin
    Alkonyi, Balint
    Papp, Elod
    Keszthelyi, Zsuzsa
    Kesmarky, Gabor
    Toth, Kalman
    [J]. INTERNATIONAL JOURNAL OF CARDIOLOGY, 2007, 120 (02) : 188 - 192
  • [6] Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin
    Gilard, Martine
    Arnaud, Bertrand
    Cornily, Jean-Christophe
    Le Gal, Gregoire
    Lacut, Karine
    Le Calvez, Genevive
    Mansourati, Jacques
    Mottier, Dominique
    Abgrall, Jean-Francois
    Boschat, Jacques
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 51 (03) : 256 - 260
  • [7] Clopidogrel for coronary stenting - Response variability, drug resistance, and the effect of pretreatment platelet reactivity
    Gurbel, PA
    Bliden, KP
    Hiatt, BL
    O'Connor, CM
    [J]. CIRCULATION, 2003, 107 (23) : 2908 - 2913
  • [8] Cytochrorne P4502C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
    Hulot, Jean-Sebastien
    Bura, Alessandra
    Villard, Eric
    Azizi, Michel
    Remones, Veronique
    Goyenvalle, Catherine
    Aiach, Martine
    Lechat, Philippe
    Gaussem, Pascale
    [J]. BLOOD, 2006, 108 (07) : 2244 - 2247
  • [9] Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance
    Lau, WC
    Gurbel, PA
    Watkins, PB
    Neer, CJ
    Hopp, AS
    Carville, DGM
    Guyer, KE
    Tait, AR
    Bates, ER
    [J]. CIRCULATION, 2004, 109 (02) : 166 - 171
  • [10] Cytochrome P-450 Polymorphisms and Response to Clopidogrel.
    Mega, Jessica L.
    Close, Sandra L.
    Wiviott, Stephen D.
    Shen, Lei
    Hockett, Richard D.
    Brandt, John T.
    Walker, Joseph R.
    Antman, Elliott M.
    Macias, William
    Braunwald, Eugene
    Sabatine, Marc S.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (04) : 354 - 362
12