The Sensitive and Selective Optical Detection of Mercury(II) Ions by Using a Phosphorothioate DNAzyme Strategy

被引：41
作者：
Zhang, Dan
Deng, Minggang
Xu, Liang
Zhou, Yangyang
Yuwen, Jing
Zhou, Xiang [1 ,2 ]
机构：
[1] Wuhan Univ, Coll Chem & Mol Sci, Key Lab Biomed Polymers, Minist Educ, Wuhan 430072, Peoples R China
[2] Beijing Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2009年 / 15卷 / 33期
关键词：
mecury ions; optical detection; phosphorothioate DNAzyme; sensors; TELOMERIC G-QUADRUPLEX; COLORIMETRIC DETECTION; PEROXIDASE-ACTIVITY; CATALYTIC BEACONS; HG2+ IONS; IN-VITRO; TURN-ON; DNA; SENSOR; COMPLEXES;
D O I：
10.1002/chem.200901268
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A study was conducted to develop a new approach to form G-quadruplex complexes efficiently by modifying the sequence. The study also investigated the use of these conformations as functional probes. The investigations were conducted using a phosphorothioate DNAzyme strategy. The phosphorothioate DNAzyme strategy was used to perform sensitive and selective optical detection of mercury(II) ions. The utilization of the DNAzyme operated by the phosphorothioate G-quadruplex formed from T4G4-S 3 combined the advantage of sensitive and selective optical detection of mercury(II) ions. The modification of oligonuleotides with sulfur and the regulation of the phosphorothioate G-quadruplex by metal ions such as Hg 2+ were also combined to develop the strategy for sensitive and selective optical detection of mercury(II) ions.
引用
收藏
页码：8117 / 8120
页数：4
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