Discovery of multi-drug resistant, MCR-1 and ESBL-coproducing ST117 Escherichia coli from diseased chickens in northeast China

被引：12
|
作者：
Ding, Sijia [1 ]
Han, Xiaohu [2 ]
Li, Jun [3 ,4 ]
Gao, Weifan [2 ]
Chen, Zeliang [2 ]
Feng, Youjun [3 ]
机构：
[1] Zhejiang Chinese Med Univ, Sch Stomatol, Hangzhou 310053, Zhejiang, Peoples R China
[2] Shenyang Agr Univ, Coll Anim Sci & Vet Med, Key Lab Zoonot Liaoning Prov, Shenyang 110866, Liaoning, Peoples R China
[3] Zhejiang Univ, Coll Anim Sci, Hangzhou 310058, Zhejiang, Peoples R China
[4] Zhejiang Univ Technol, Coll Biotechnol & Bioengn, Hangzhou 310014, Zhejiang, Peoples R China
来源：
SCIENCE BULLETIN | 2018年 / 63卷 / 16期
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
Lipid A; MCR-1; Colistin resistance; Transferable resistance to polymyxin; Intrinsic colistin resistance; Gut bacteria; Microbiome; RESOLUTION CRYSTAL-STRUCTURE; VI SECRETION; CATALYTIC DOMAIN; BETA-LACTAMASE; GENE MCR-1; PLASMID; PREVALENCE; EMERGENCE; PHNSHP45; INSIGHTS;
D O I：
10.1016/j.scib.2018.07.017
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
An endemic multi-drug resistant ST117 E. coli isolate coproducing MCR-1 and 3 ESBL loci was, for the first time, detected from diseased chicken, Liaoning Province, in Northeast China, from 2011 to 2012. Whole-genome sequencing revealed 5 unique plasmids, namely pHXH-1, pHXH-2, pHXH-3, pHXH-4 and pHXH-5). Among them, pHXH1 and pHXH4 encode ESBL, and pHXH-5 mediates MCR-1 colistin resistance. The results indicate that the potentially-national dissemination of MCR-1-positive pathogens with pan-drug resistance proceeds via food chains. (C) 2018 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved.
引用
收藏
页码：1059 / 1066
页数：8
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