Mn(i)-Catalyzed nucleophilic addition/ring expansion via C-H activation and C-C cleavage

被引：12
作者：
Liu, Bingxian [1 ]
Yuan, Yin [1 ]
Hu, Panjie [1 ]
Zheng, Guangfan [2 ]
Bai, Dachang [1 ]
Chang, Junbiao [1 ]
Li, Xingwei [1 ,2 ]
机构：
[1] Henan Normal Univ, Collaborat Innovat Ctr Henan Prov Green Mfg Fine, Sch Chem & Chem Engn, Henan Key Lab Organ Funct Mol & Drug Innovat, Xinxiang 453007, Henan, Peoples R China
[2] Shaanxi Normal Univ SNNU, Sch Chem & Chem Engn, Xian 710062, Shaanxi, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 72期
关键词：
MANGANESE-CATALYZED SYNTHESIS; 1,3-DICARBONYL COMPOUNDS; FUNCTIONALIZATION; ALKYNES; ANNULATION; HETEROARENES; ALDEHYDES; INDOLES; KETONES; IMINES;
D O I：
10.1039/c9cc05973c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Mn(i)-Catalyzed synthesis of seven- or eight-membered carbocycles is disclosed via C-H activation of heteroarenes and coupling with alkyne-functionalized 1,3-cyclopentadiones or 1,3-cyclohexadiones. This n to n + 2 (n = 5, 6) ring expansion reaction proceeded via a C-H alkenylation/carbonyl addition/retro-Aldol cascade. Structurally diverse mid-sized carbocycles were constructed via cleavage of both C-H and C-C bonds in a single operation.
引用
收藏
页码：10764 / 10767
页数：4
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