Mn(i)-Catalyzed nucleophilic addition/ring expansion via C-H activation and C-C cleavage

被引：12

作者：

Liu, Bingxian ^{[1
]}

Yuan, Yin ^{[1
]}

Hu, Panjie ^{[1
]}

Zheng, Guangfan ^{[2
]}

Bai, Dachang ^{[1
]}

Chang, Junbiao ^{[1
]}

Li, Xingwei ^{[1
,2
]}

机构：

[1] Henan Normal Univ, Collaborat Innovat Ctr Henan Prov Green Mfg Fine, Sch Chem & Chem Engn, Henan Key Lab Organ Funct Mol & Drug Innovat, Xinxiang 453007, Henan, Peoples R China

[2] Shaanxi Normal Univ SNNU, Sch Chem & Chem Engn, Xian 710062, Shaanxi, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 72期

关键词：

MANGANESE-CATALYZED SYNTHESIS; 1,3-DICARBONYL COMPOUNDS; FUNCTIONALIZATION; ALKYNES; ANNULATION; HETEROARENES; ALDEHYDES; INDOLES; KETONES; IMINES;

D O I：

10.1039/c9cc05973c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Mn(i)-Catalyzed synthesis of seven- or eight-membered carbocycles is disclosed via C-H activation of heteroarenes and coupling with alkyne-functionalized 1,3-cyclopentadiones or 1,3-cyclohexadiones. This n to n + 2 (n = 5, 6) ring expansion reaction proceeded via a C-H alkenylation/carbonyl addition/retro-Aldol cascade. Structurally diverse mid-sized carbocycles were constructed via cleavage of both C-H and C-C bonds in a single operation.

引用

页码：10764 / 10767

页数：4

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