Antinociceptive Effect of Crude Extract, Fractions and Three Alkaloids Obtained from Fruits of Piper tuberculatum

被引：32

作者：

Rodrigues, Rosely Valeria ^{[2
]}

Lanznaster, Debora ^{[1
]}

Longhi Balbinot, Daniela Tagliari ^{[1
]}

Gadotti, Vinicius de Maria ^{[1
]}

Facundo, Valdir Alves ^{[2
]}

Soares Santos, Adair Roberto ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Ctr Biol Sci, Dept Physiol Sci, BR-88040900 Florianopolis, SC, Brazil

[2] Fed Univ Rondonia, Dept Med, Porto Velho, RO, Brazil

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2009年 / 32卷 / 10期

关键词：

Piper tuberculatum; Piperaceae; alkaloid; pain; acetic acid; ACETIC-ACID; PIPLARTINE; AMIDES; INVOLVEMENT; CONSTITUENTS; INHIBITION; ANTIFUNGAL;

D O I：

10.1248/bpb.32.1809

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study investigated the possible antinociceptive effect of the crude extract, fractions and pure compounds (three alkaloids) obtained from fruits of Piper tuberculatum JACQ. (Piperaceae) in acetic acid-induced visceral pain in mice. Oral administration of crude extract and fractions (CH2Cl2, EtOAc, methanol and hexane) (3-300 mg kg(-1)) caused a dose-related and significant inhibition of the acetic acid-induced visceral nociceptive response. The crude extract, dichloromethane (CH2Cl2) and ethyl acetate (EtOAc) fractions were more potent than methanol and hexane fractions. The isolated alkaloids dihydro-piplartine, piplartine and 3,4,5-trimethoxydihydrocinnamic acid (0.0001-30 mg kg(-1)) exhibited significant and dose-related antinociceptive effects against acetic acid-induced visceral pain. The results show, for the first time, that crude extract, fractions and pure compounds obtained from P tuberculatum produce marked antinociception against the acetic acid-induced visceral nociceptive response, supporting the ethnomedical use of P. tuberculatum.

引用

页码：1809 / 1812

页数：4

共 24 条

[1] In vivo growth-inhibition of Sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper [J].

Bezerra, D. P. ;

Castro, F. O. ;

Alves, A. P. N. N. ;

Pessoa, C. ;

Moraes, M. O. ;

Silveira, E. R. ;

Lima, M. A. S. ;

Elmiro, F. J. M. ;

Costa-Lotufo, L. V. .

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2006, 39 (06) :801-807

[2] In vitro and in vivo antitumor effect of 5-FU combined with piplartine and piperine [J].

Bezerra, Daniel P. ;

de Castro, Fernanda O. ;

Alves, Ana Paula N. N. ;

Pessoa, Claudia ;

de Moraes, Manoel Odorico ;

Silveira, Edilberto R. ;

Lima, Mary Anne S. ;

Elmiro, Francisca Juliana M. ;

de Alencar, Nylane M. N. ;

Mesquita, Rodney O. ;

Lima, Michael W. ;

Costa-Lotufo, Leticia V. .

JOURNAL OF APPLIED TOXICOLOGY, 2008, 28 (02) :156-163

[3] Piplartine induces inhibition of leukemia cell proliferation triggering both apoptosis and necrosis pathways [J].

Bezerra, Daniel Pereira ;

Gadelha Militao, Gardenia Carmen ;

de Castro, Fernanda Oliveira ;

Pessoa, Claudia ;

de Moraes, Manoel Odorico ;

Silveira, Edilberto Rocha ;

Sousa Lima, Mary Anne ;

Martins Elmiro, Francisca Juliana ;

Costa-Lotufo, Leticia Veras .

TOXICOLOGY IN VITRO, 2007, 21 (01) :1-8

[4] SOME RECENT ISOLATION STUDIES FROM POTENTIAL INSECTICIDAL PIPER SPECIES [J].

BOLL, PM ;

PARMAR, VS ;

TYAGI, OD ;

PRASAD, A ;

WENGEL, J ;

OLSEN, CE .

PURE AND APPLIED CHEMISTRY, 1994, 66 (10-11) :2339-2342

[5]

Calixto JB, 2000, PHYTOTHER RES, V14, P401, DOI 10.1002/1099-1573(200009)14:6<401::AID-PTR762>3.0.CO

[6]

2-H

[7] ABDOMINAL CONSTRICTION RESPONSE AND ITS SUPPRESSION BY ANALGESIC DRUGS IN MOUSE [J].

COLLIER, HOJ ;

DINNEEN, LC ;

JOHNSON, CA ;

SCHNEIDER, C .

BRITISH JOURNAL OF PHARMACOLOGY, 1968, 32 (02) :295-+

[8] Chemical composition and larvicidal activity of essential oils from Piper species [J].

de Morals, Selene Maia ;

Facundo, Valdir Alves ;

Bertini, Luciana Medeiros ;

Cavalcanti, Eveline Solon Barreira ;

dos Anjos, Joao Francisco, Jr. ;

Ferreira, Silane Aparecida ;

de Brito, Edy Sousa ;

Neto, Manoel Alves de Souza .

BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2007, 35 (10) :670-675

[9] Antinociceptive properties of the hydroalcoholic extract and preliminary study of a xanthone isolated from Polygala cypariassias (Polygalaceae) [J].

deCampos, ROP ;

Santos, ARS ;

Vaz, ZR ;

Pinheiro, TR ;

Pizzolatti, MG ;

Cechinel, V ;

DelleMonache, F ;

Yunes, RA ;

Calixto, JB .

LIFE SCIENCES, 1997, 61 (16) :1619-1630

[10] Constituents of Piper alatabaccum Trel & Yuncker (Piperaceae) [J].

Facundo, VA ;

da Silveira, ASP ;

Morais, SM .

BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2005, 33 (07) :753-756

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