Microbiome and pancreatic ductal adenocarcinoma

被引：26

作者：

Tijeras-Raballand, Annemilai ^{[1
]}

Hilmi, Marc ^{[1
,2
]}

Astorgues-Xerri, Lucile ^{[1
]}

Nicolle, Remy ^{[1
,3
]}

Bieche, Ivan ^{[4
]}

Neuzillet, Cindy ^{[1
,2
]}

机构：

[1] OncoMEGA, Lamorlaye, France

[2] Versailles St Quentin Univ UVQ, Curie Inst, Med Oncol Dept, Paris Saclay Univ, 35 Rue Dailly, F-92210 St Cloud, France

[3] La Ligue Canc, Tumors Ident Card, Paris, France

[4] Curie Inst, Genet Dept, Pharmacogen Unit, Paris, France

来源：

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY | 2021年 / 45卷 / 02期

关键词：

Dysbiosis; Fungi; Intratumor bacteria; Microbiota; Pancreatic cancer; TUMOR MICROBIOME; CANCER; DISPARITY; BACTERIA; DISEASE; COHORT;

D O I：

10.1016/j.clinre.2020.101589

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pancreatic ductal adenocarcinoma (PDAC) incidence and related-deaths are increasing worldwide. PDAC is characterized by poor prognosis due to late diagnosis, high metastatic capacity and resistance to therapy. This is partially due to its specific microenvironment, where the stroma is prominent over tumor cells. Besides the oral and gut microbiota, the intratumor microbiome, i.e. the bacterial and fungal microorganisms present within the tumor, was recently introduced as a new partner of the tumor microenvironment of PDAC modulating pancreatic carcinogenesis, intratumor immune infiltrates, and response to chemotherapy. In this review, we propose an overview of current knowledge about the roles of bacteria and fungi in PDAC development and biology, and discuss potential therapeutic implications. ? 2020 Elsevier Masson SAS. All rights reserved.

引用

页数：6

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