Immunological and Biochemical Correlates of Adjunctive Dexamethasone in Vietnamese Adults with Bacterial Meningitis

被引：8

作者：

Nguyen Thi Hoang Mai ^{[2
]}

Trung Vu Tuan ^{[1
]}

Wolbers, Marcel ^{[1
,3
]}

Dang Minh Hoang ^{[1
]}

Tran Vu Thieu Nga ^{[1
]}

Tran Thi Hong Chau ^{[2
]}

Ly Van Chuong ^{[2
]}

Dinh Xuan Sinh ^{[2
]}

Ho Dang Trung Nghia ^{[2
]}

Nguyen Duy Phong ^{[2
]}

Nguyen Hoan Phu ^{[2
]}

To Song Diep ^{[2
]}

Hoang Thi Thanh Hang ^{[1
]}

Nguyen van Vinh Chau ^{[2
]}

Farrar, Jeremy ^{[1
,3
]}

Schultsz, Constance ^{[1
,3
,4
]}

Tran Tinh Hien ^{[2
]}

Simmons, Cameron P. ^{[1
,3
]}

机构：

[1] Univ Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam

[2] Hosp Trop Dis, Ho Chi Minh City, Vietnam

[3] Univ Oxford, Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford, England

[4] Univ Amsterdam, Acad Med Ctr, Ctr Poverty Related Communicable Dis, NL-1105 AZ Amsterdam, Netherlands

来源：

CLINICAL INFECTIOUS DISEASES | 2009年 / 49卷 / 09期

基金：

英国惠康基金;

关键词：

CEREBROSPINAL-FLUID; CONTROLLED TRIAL; B MENINGITIS; DOUBLE-BLIND; CORTICOSTEROIDS; CHILDREN;

D O I：

10.1086/630207

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Adjunctive treatment to improve outcome from bacterial meningitis has centered on dexamethasone. Among Vietnamese patients with bacterial meningitis, cerebrospinal fluid (CSF) opening pressure and CSF: plasma glucose ratios were significantly improved and levels of CSF cytokines interleukin (IL)-6, IL-8, and IL-10 and were all statistically significantly lower after treatment in patients who were randomized to dexamethasone, compared with levels in patients who received placebo.

引用

页码：1387 / 1392

页数：6

共 19 条

[1] 875 CASES OF BACTERIAL-MENINGITIS .1. CLINICAL-DATA, PROGNOSIS, AND THE ROLE OF SPECIALIZED HOSPITAL DEPARTMENTS [J].