Cyclin D-Cdk4 and cyclin E-Cdk2 regulate the JAK/STAT signal transduction pathway in Drosophila

被引：44
作者：
Chen, X [1 ]
Oh, SW [1 ]
Zheng, ZY [1 ]
Chen, HW [1 ]
Shin, HH [1 ]
Hou, SX [1 ]
机构：
[1] NCI, Frederick Canc Res & Dev Ctr, Immunobiol Lab, NIH, Frederick, MD 21702 USA
来源：
DEVELOPMENTAL CELL | 2003年 / 4卷 / 02期
关键词：
D O I：
10.1016/S1534-5807(03)00024-8
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The JAK/STAT signal transduction pathway regulates many developmental processes in Drosophila. However, the functional mechanism of this pathway is poorly understood. In this report, we identify the Drosophila cyclin-dependent kinase 4 (Cdk4), which exhibits embryonic mutant phenotypes identical to those in the Hopscotch/JAK kinase and stat92E/STAT mutations. Specific genetic interactions between Cdk4 and hop mutations suggest that Cdk4 functions downstream of the HOP tyrosine kinase. We further show that Cyclin D-Cdk4 (as well as Cyclin E-Cdk2) binds and regulates STAT92E protein stability. STAT92E regulates gene expression for various biological processes, including the endocycle S phase. These data suggest that Cyclin D-Cdk4 and Cyclin E-Cdk2 play more versatile roles in Drosophila development.
引用
收藏
页码：179 / 190
页数：12
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