A Mild, Fast, and Scalable Synthesis of Substituted α-Acyloxy Ketones via Multicomponent Reaction Using a Continuous Flow Approach

被引：7

作者：

Salvador, Carlos Eduardo M. ^{[1
]}

Andrade, Carlos Kleber Z. ^{[1
]}

机构：

[1] Univ Brasilia, Inst Quim, Lab Quim Metodol & Organ Sintet, Brasilia, DF, Brazil

来源：

FRONTIERS IN CHEMISTRY | 2019年 / 7卷

关键词：

continuous flow; alpha-acyloxy ketones; Passerini reaction; microwaves; multicomponent reactions; CHEMISTRY; EFFICIENT;

D O I：

10.3389/fchem.2019.00531

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A continuous flow approach for the synthesis of alpha-acyloxy ketone derivatives from the corresponding arylglyoxals, isocyanides, and carboxylic acids is described. The target products were obtained in excellent yields in short residence times and with high purities via the first transcription of the microwave-to-flow paradigm to the isocyanide-based Passerini reaction. Furthermore, this methodology allowed a 10-fold scale-up using the same experimental conditions initially established.

引用

页数：10

共 34 条

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