Supramolecular Stacking of Doxorubicin on Carbon Nanotubes for In Vivo Cancer Therapy

被引：447

作者：

Liu, Zhuang ^{[2
,3
]}

Fan, Alice C. ^{[1
]}

Rakhra, Kavya ^{[1
]}

Sherlock, Sarah ^{[2
]}

Goodwin, Andrew ^{[2
]}

Chen, Xiaoyuan ^{[4
]}

Yang, Qiwei ^{[1
]}

Felsher, Dean W. ^{[1
]}

Dai, Hongjie ^{[2
]}

机构：

[1] Stanford Univ, Sch Med, Div Oncol, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

[3] Soochow Univ, Funct Nano & Soft Mat Lab FUNSCM, Suzhou 215123, Jiangsu, Peoples R China

[4] Stanford Univ, Sch Med, Dept Radiol, Stanford, CA 94305 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 41期

基金：

美国国家卫生研究院;

关键词：

cancer; drug delivery; nanotubes; pi interactions; nano-biotechnology; LIPOSOMAL DOXORUBICIN; RAMAN-SPECTROSCOPY; DRUG-DELIVERY; LIVING MICE; TUMOR; CELLS; PHARMACOKINETICS; THERAPEUTICS; TRANSPORTERS; CHEMOTHERAPY;

D O I：

10.1002/anie.200902612

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The evidence is stacking up: Many therapeutic advantages such as prolonged circulation in the blood, increased tumor drug uptake, enhanced therapeutic efficacy, and markedly reduced toxic side effects are provided by a carbon nanotube based chemotherapeutic formulation (see picture). In this system, doxorubicin (DOX) is loaded onto the sidewalls of functionalized single-walled carbon nanotubes by supramolecular π-π stacking. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7668 / 7672

页数：5

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