Quassinoid constituents of Quassia amara L. leaf herbal tea. Impact on its antimalarial activity and cytotoxicity

被引：37

作者：

Houel, Emeline

Bertani, Stephane ^{[2
]}

Bourdy, Genevieve ^{[3
,4
]}

Deharo, Eric ^{[3
,4
]}

Jullian, Valerie ^{[3
,4
]}

Valentin, Alexis ^{[3
,4
]}

Chevalley, Severine ^{[3
,4
]}

Stien, Didier ^{[1
]}

机构：

[1] Univ Antilles Guyane, CNRS, UMR Ecofog, Inst Enseignement Super Guyane, F-97337 Cayenne, France

[2] Museum Natl Hist Nat, USM 0307, Lab Parasitol Comparee & Modeles Expt, F-75231 Paris, France

[3] Univ Toulouse, UPS, UMR 152, Lab Pharmacochim Subst Nat & Pharmacophores Redox, F-31062 Toulouse 9, France

[4] Univ Toulouse 3, Fac Pharmaceut Sci, UMR 152, Inst Rech Dev, F-31062 Toulouse, France

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2009年 / 126卷 / 01期

关键词：

Quassia amara L; Simaroubaceae; Leaf tea; Antimalarial activity; Cytotoxicity; Simalikalactone D; SIMALIKALACTONE-D; FRENCH-GUIANA; SIMAROUBACEAE; REMEDIES; INVITRO;

D O I：

10.1016/j.jep.2009.07.037

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Aim of the study: Our objective was to assess whether it could be contemplated to recommend Quassia amara young leaf tea for treatment against malaria. and if yes. set up a standard protocol for preparing the herbal tea. Materials and methods: The leaf tea was extracted with methylene chloride and the organic extract was fractionated with HPLC. Pure compounds were characterized and their in vitro cytotoxicity and antiplasmodial activity was determined. Results and discussion: We discovered that antimalarial Quassia amara young leaf tea contains several quassinoids: simalikalactone D (SkD. 1), picrasin B (2). picrasin H (3), neoquassin (4), quassin (5), picrasin 1(6) and picrasin J (7). These last two compounds are new. In addition. our experiments demonstrate that both biological activity and cytotoxicity of the remedy may be attributed solely to the presence of SkD. Conclusion: In conclusion, this preparation Should not be recommended for treatment of malaria until a clinical Study in humans is performed with SkD. (C) 2009 Elsevier Ireland Ltd. All rights reserved

引用

页码：114 / 118

页数：5

共 20 条

[1] Antiviral activity of simalikalactone D, a quassinoid from Quassia africana [J].