Preparation of functionalized alkenylmagnesium bromides via a bromine-magnesium exchange

被引：45

作者：

Thibonnet, J ^{[1
]}

Knochel, P ^{[1
]}

机构：

[1] Univ Munich, Dept Chem, D-81377 Munich, Germany

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 18期

关键词：

magnesium; functionalized organometallics; nitrile; sulfone;

D O I：

10.1016/S0040-4039(00)00387-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Bromonitriles, such as 1, 2 or the alpha-bromosulfone 3, undergo a smooth bromine-magnesium exchange with isopropylmagnesium bromide furnishing new functionalized organomagnesium species which react smoothly with various electrophiles like Me3SiCl, Bu3SnCl, allyl bromides, aldehydes, ketones or acid chlorides providing the expected products of type 7, 8 or 9. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3319 / 3322

页数：4

共 16 条

[1] Bromine-magnesium-exchange as a general tool for the preparation of polyfunctional aryl and heteroaryl magnesium-reagents [J].