Enantioselective Electroreductive Coupling of Alkenyl and Benzyl Halides via Nickel Catalysis

被引：226

作者：

DeLano, Travis J. ^{[1
]}

Reisman, Sarah E. ^{[1
]}

机构：

[1] CALTECH, Div Chem & Chem Engn, Warren & Katharine Schlinger Lab Chem & Chem Engn, Pasadena, CA 91125 USA

来源：

ACS CATALYSIS | 2019年 / 9卷 / 08期

基金：

美国国家科学基金会;

关键词：

nickel; electrochemistry; enantioselective; cross-coupling; asymmetric catalysis; ARYL HALIDES;

D O I：

10.1021/acscatal.9b01785

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

An electrochemically driven enantioselective nickel-catalyzed reductive cross-coupling of alkenyl bromides and benzyl chlorides is reported. The reaction forms products bearing allylic stereogenic centers with good enantioselectivity under mild conditions in an undivided cell. Electrochemical activation and turnover of the catalyst mitigate issues posed by metal powder reductants. This report demonstrates that enantioselective Ni-catalyzed cross-electrophile couplings can be driven electrochemically.

引用

页码：6751 / 6754

页数：7

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