Anti-Inflammatory and anti-proliferative oleanane-type triterpene glycosides from the vine of Momordica cochinchinensis

被引：2

作者：

Huang, Hung-Tse ^{[1
,2
]}

Lin, Yu-Chi ^{[1
]}

Zhang, Li-Jie ^{[1
]}

Liaw, Chia-Ching ^{[1
,3
]}

Chen, Hsin-Yen ^{[4
]}

Hsueh, Ming-Tung ^{[4
]}

Kuo, Yao-Haur ^{[1
,5
]}

机构：

[1] Natl Res Inst Chinese Med, Div Chinese Mat Med Dev, Taipei, Taiwan

[2] Natl Taiwan Univ, Dept Biochem Sci & Technol, Taipei, Taiwan

[3] Natl Chiayi Univ, Dept Biochem Sci & Technol, Chiayi, Taiwan

[4] Council Agr, Taitung Dist Agr Res & Extens Stn, Taitung, Taiwan

[5] China Med Univ, Coll Chinese Med, Grad Inst Integrated Med, Taichung, Taiwan

来源：

NATURAL PRODUCT RESEARCH | 2021年 / 35卷 / 16期

关键词：

Momordica cochinchinensis; oleanane-type triterpene glycoside; mocochinoside; anti-inflammatory; anti-proliferation; SAPONINS; EXTRACT; BARK; ACID;

D O I：

10.1080/14786419.2019.1666383

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This research isolated two new oleanane-type triterpene glycosides, named mocochinosides A (1) and B (2), together with ten known compounds as chikusetsusaponin IVa ethyl ester (3), momordin Ib (4), momordin IIb (5), momordin II (6), calenduloside G (7), calenduloside H (8), elatoside A (9), elatoside C (10), calendulaglycoside C 6'-O-7-butyl ester (11), and hederagenin 3-O-beta-D-glucuronopyranoside (12) and characterized them from the vines of Momordica cochinchinensis. The new structures of both glycosides 1-2 were elucidated by spectroscopic analysis including 2 D NMR and MS, followed by an analysis of their anti-inflammatory and cytotoxic activities. Compounds 1, 4, and 11 showed moderate inhibitions for NO production on RAW264.7 macrophages induced by LPS at IC50 5.41 similar to 11.28 mu M. Compounds 3, 4, and 7 (IC50 8.42 similar to 19.74 mu M) exhibited potential anti-proliferative activities against both of WiDr and MCF-7 human tumor cell lines.

引用

页码：2707 / 2714

页数：8

共 22 条

[1] Assay of nutritional composition and antioxidant activity of three dioecious Momordica species of south east Asia
Bharathi L.K.
Singh H.S.
Shivashankar S.
Ganeshamurthy A.N.
Sureshkumar P.
[J]. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences, 2014, 84 (1) : 31 - 36
[2] A new multiflorane triterpenoid ester from Momordica cochinchinensis Spreng
De Shan, M
Hu, LH
Chen, ZL
[J]. NATURAL PRODUCT LETTERS, 2001, 15 (02): : 139 - 145
[3] Gao X.M, 2005, CHINESE MAT MED, P601
[4] TRITERPENOID GLUCURONIDE SAPONINS FROM ROOT BARK OF ARALIA-ARMATA
HU, M
OGAWA, K
SASHIDA, Y
XIAO, PG
[J]. PHYTOCHEMISTRY, 1995, 39 (01) : 179 - 184
[5] TRITERPENOIDS OF AKEBIA-QUINATA CALLUS-TISSUE
IKUTA, A
ITOKAWA, H
[J]. PHYTOCHEMISTRY, 1986, 25 (07) : 1625 - 1628
[6] Fatty acid and carotenoid composition of gac (Momordica cochinchinensis Spreng) fruit
Ishida, BK
Turner, C
Chapman, MH
McKeon, TA
[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2004, 52 (02) : 274 - 279
[7] Anti-gastritis and wound healing effects of Momordicae Semen extract and its active component
Jung, Kiwon
Chin, Young-Won
Chung, Yoon Hee
Park, Yang Hae
Yoo, Hunseung
Min, Dong Sun
Lee, Bongyong
Kim, Jinwoong
[J]. IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2013, 35 (01) : 126 - 132
[8] SAPONINS FROM ROOTS OF MOMORDICA-COCHINCHINENSIS
KAWAMURA, N
WATANABE, H
OSHIO, H
[J]. PHYTOCHEMISTRY, 1988, 27 (11) : 3585 - 3591
[9] KIZU H, 1985, CHEM PHARM BULL, V33, P3324
[10] Phytochemicals and antioxidant activity of different fruit fractions (peel, pulp, aril and seed) of Thai gac (Momordica cochinchinensis Spreng)
Kubola, Jittawan
Siriamornpun, Sirithon
[J]. FOOD CHEMISTRY, 2011, 127 (03) : 1138 - 1145

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