Michael addition of nitromethane to non-racemic chiral Cr(CO)3 complexes of ethyl cinnamate derivatives:: stereoselective synthesis of (R)-(-)-baclofen

被引：34
作者：
Baldoli, C
Maiorana, S
Licandro, E
Perdicchia, D
Vandoni, B
机构：
[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy
[2] CNR, Ctr Studio Sintesi Stereochim Speciali Sistmi Org, I-20133 Milan, Italy
来源：
TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 09期
关键词：
D O I：
10.1016/S0957-4166(00)00123-3
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
We carried out a highly stereoselective Michael addition (96% de) of nitromethane to enantiomerically pure tricarbonyl (ethyl-4-chloro-2-trimethylsilylcinnamate)chromium(0). This reaction is the key step in the synthesis of(R)-(-)-baclofen, a potent antispastic drug. (C) 2000 Elsevier Science Ltd. All rights reserved.
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页码：2007 / 2014
页数：8
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