Novel Gottingen Miniswine Model of Heart Failure With Preserved Ejection Fraction Integrating Multiple Comorbidities

被引：39

作者：

Sharp, Thomas E., III ^{[1
]}

Scarborough, Amy L. ^{[1
]}

Li, Zhen ^{[1
]}

Polhemus, David J. ^{[1
]}

Hidalgo, Hunter A. ^{[1
,2
]}

Schumacher, Jeffery D. ^{[3
]}

Matsuura, Timothy R. ^{[4
]}

Jenkins, J. Stephen ^{[5
]}

Kelly, Daniel P. ^{[4
]}

Goodchild, Traci T. ^{[1
,2
]}

Lefer, David J. ^{[1
,2
]}

机构：

[1] Louisiana State Univ, Cardiovasc Ctr Excellence, Sch Med, Hlth Sci Ctr, New Orleans, LA 70112 USA

[2] Louisiana State Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Hlth Sci Ctr, New Orleans, LA 70112 USA

[3] Louisiana State Univ, Dept Anim Care, Hlth Sci Ctr, New Orleans, LA 70112 USA

[4] Univ Penn, Dept Med, Cardiovasc Inst, Perelman Sch Med, Philadelphia, PA 19104 USA

[5] Ochsner Med Ctr, Heart & Vasc Inst, Dept Cardiol, New Orleans, LA USA

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2021年 / 6卷 / 02期

基金：

美国国家卫生研究院;

关键词：

animal models of human disease; obesity; metabolic syndrome; hypertension; heart failure with preserved ejection fraction; METABOLIC SYNDROME; EUROPEAN-SOCIETY; WORKING GROUP; DIAGNOSIS; SWINE;

D O I：

10.1016/j.jacbts.2020.11.012

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A lack of preclinical large animal models of heart failure with preserved ejection fraction (HFpEF) that recapitulate this comorbid-laden syndrome has led to the inability to tease out mechanistic insights and to test novel therapeutic strategies. This study developed a large animal model that integrated multiple comorbid determinants of HFpEF in a miniswine breed that exhibited sensitivity to obesity, metabolic syndrome, and vascular disease with overt clinical signs of heart failure. The combination of a Western diet and 11-deoxycorticosterone acetate salt-induced hypertension in the Gottingen miniswine led to the development of a novel large animal model of HFpEF that exhibited multiorgan involvement and a full spectrum of comorbidities associated with human HFpEF. (C) 2021 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

引用

页码：154 / 170

页数：17

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