Synthetic Enzyme-Catalyzed CO2 Fixation Reactions

被引：67

作者：

Aleku, Godwin A. ^{[1
]}

Roberts, George W. ^{[2
]}

Titchiner, Gabriel R. ^{[2
]}

Leys, David ^{[2
]}

机构：

[1] Univ Cambridge, Dept Biochem, 80 Tennis Court Rd, Cambridge CB2 1GA, England

[2] Univ Manchester, Dept Chem, Manchester Inst Biotechnol, 131 Princess St, Manchester M1 7DN, Lancs, England

来源：

CHEMSUSCHEM | 2021年 / 14卷 / 08期

基金：

英国生物技术与生命科学研究理事会;

关键词：

biocatalysis; carboxylation; cascade reactions; CO2; fixation; enzymes; ACID;

D O I：

10.1002/cssc.202100159

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In recent years, (de)carboxylases that catalyze reversible (de)carboxylation have been targeted for application as carboxylation catalysts. This has led to the development of proof-of-concept (bio)synthetic CO2 fixation routes for chemical production. However, further progress towards industrial application has been hampered by the thermodynamic constraint that accompanies fixing CO2 to organic molecules. In this Review, biocatalytic carboxylation methods are discussed with emphases on the diverse strategies devised to alleviate the inherent thermodynamic constraints and their application in synthetic CO2-fixation cascades.

引用

页码：1781 / 1804

页数：24

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