Reversion from prediabetes to normoglycaemia after weight change in older persons: The KORA F4/FF4 study

被引：12

作者：

Kowall, Bernd ^{[1
]}

Rathmann, Wolfgang ^{[2
,3
]}

Kuss, Oliver ^{[2
,3
]}

Herder, Christian ^{[3
,4
,5
]}

Roden, Michael ^{[3
,4
,5
]}

Stang, Andreas ^{[1
]}

Huth, Cornelia ^{[3
,6
]}

Thorand, Barbara ^{[3
,6
]}

Meisinger, Christa ^{[7
,8
]}

Peters, Annette ^{[3
,6
]}

机构：

[1] Univ Duisburg Essen, Ctr Clin Epidemiol, Inst Med Informat Biometry & Epidemiol, Med Fac, Essen, Germany

[2] Heinrich Heine Univ, Inst Biometr & Epidemiol, German Diabet Ctr, Leibniz Ctr Diabet Res, Dusseldorf, Germany

[3] German Ctr Diabet Res DZD, Munich, Germany

[4] Heinrich Heine Univ, Inst Clin Diabetol, German Diabet Ctr, Leibniz Ctr Diabet Res, Dusseldorf, Germany

[5] Heinrich Heine Univ, Med Fac, Div Endocrinol & Diabetol, Dusseldorf, Germany

[6] Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany

[7] Ludwig Maximilian Univ Munchen, Chair Epidemiol, UNIKA T Augsburg, Augsburg, Germany

[8] Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Independent Res Grp Clin Epidemiol, Neuherberg, Germany

来源：

NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 2021年 / 31卷 / 02期

关键词：

Prediabetes; Normal glucose tolerance; HbA1c; Body mass index; Waist circumference; Weight reduction; Cardiovascular risk; IMPAIRED GLUCOSE-TOLERANCE; FASTING GLUCOSE; RISK; POPULATION; REGRESSION; REDUCTION; GLYCEMIA; GERMANY; PEOPLE;

D O I：

10.1016/j.numecd.2020.09.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background and aims: In a non-interventional study of older persons, we assessed the impact of changes in BMI and waist circumference (WC) on reversion from glucose- and HbA1c-defined prediabetes to normoglycaemia (in short: reversion) and on persistence of normoglycaemia. Moreover, we studied whether reversion reduced cardiovascular risk. Methods and results: From the population-based KORA S4/F4/FF4 cohort study conducted in Southern Germany, we utilized data from the second and third visit to the study center (median follow-up 6.5 years). We used two overlapping data sets, one with 563 persons with HbA1c<6.5% (mean age 69 years, 51.5% men), one with 510 persons with glucose-based prediabetes or normal glucose tolerance. We calculated proportions of reversion, and estimated adjusted relative risks for the association between initial BMI/WC and change of BMI/WC, respectively, and reversion (and persistence of normoglycaemia, respectively). We estimated 10-year cardiovascular risks using the Framingham 2008 score. Overall, 27.3% of persons with HbA1c-defined prediabetes and 9.2% of persons with glucose-based prediabetes returned to normoglycaemia during follow-up. Lower initial BMI/WC and reduction of BMI/WC were associated with larger probabilities of returning to normoglycaemia (e.g., for HbA1c 5.7-6.4%, RR = 1.24 (95% CI: 1.09-1.41) per 1 kg/m(2) decline of BMI). Moreover, reduction of BMI/WC increased probabilities of maintaining normoglycaemia (e.g., for glucose-based prediabetes, RR = 1.09 (1.02-1.16) per 1 kg/m(2) decline of BMI). 10-year cardiovascular risk was 5.6 (1.7-9.6) percentage points lower after reversion from glucose-based prediabetes to normoglycaemia. Conclusion: In older adults, even moderate weight reduction contributes to reversion from pre-diabetes to normoglycaemia and to maintaining normoglycaemia. (C) 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

引用

页码：429 / 438

页数：10

共 37 条

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