Adjuvant concurrent chemoradiation therapy (CCRT) alone versus CCRT followed by adjuvant chemotherapy: Which is better in patients with radically resected extrahepatic biliary tract cancer?: a non-randomized, single center study

被引:35
作者
Lim, Kyu-Hyoung [1 ]
Oh, Do-Youn [1 ,4 ]
Chie, Eui Kyu [2 ]
Jang, Jin-Young [3 ]
Im, Seock-Ah [1 ,4 ]
Kim, Tae-You [1 ,4 ]
Kim, Sun-Whe [3 ]
Ha, Sung Whan [2 ]
Bang, Yung-Jue [1 ,4 ]
机构
[1] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea
[2] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Radiat Oncol, Seoul, South Korea
[3] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Dept Surg, Seoul, South Korea
[4] Seoul Natl Univ, Coll Med, Seoul Natl Univ Hosp, Canc Res Inst, Seoul, South Korea
关键词
BILE-DUCT CANCER; POSTOPERATIVE RADIOTHERAPY; HILAR CHOLANGIOCARCINOMA; GALLBLADDER CARCINOMA; RADIATION-THERAPY; PHASE-II; MANAGEMENT; SURVIVAL; PATTERNS; TRIAL;
D O I
10.1186/1471-2407-9-345
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: There is currently no standard adjuvant therapy for patients with curatively resected extrahepatic biliary tract cancer (EHBTC). The aim of this study was to analyze the clinical features and outcomes between patients undergoing adjuvant concurrent chemoradiation therapy (CCRT) alone and those undergoing CCRT followed by adjuvant chemotherapy after curative resection. Methods: We included 120 patients with EHBTC who underwent radical resection and then received adjuvant CCRT with or without further adjuvant chemotherapy between 2000 and 2006 at Seoul National University Hospital. Results: Out of 120 patients, 30 received CCRT alone, and 90 received CCRT followed by adjuvant chemotherapy. Baseline characteristics were comparable between the two groups. Three-year disease-free survival (DFS) rates for CCRT alone and CCRT followed by adjuvant chemotherapy were 26.6% and 45.2% (p = 0.04), respectively, and 3-year overall survival (OS) rates were 30.8% and 62.6% (p < 0.01), respectively. CCRT followed by adjuvant chemotherapy showed longer survival than did CCRT alone, especially in R1 resection (microscopically positive margins) or negative lymph node. Conclusion: Adjuvant CCRT followed by adjuvant chemotherapy prolonged DFS and OS, compared with CCRT alone in patients with curatively resected EHBTC. Adjuvant chemotherapy deserves to consider after adjuvant CCRT. In the future, a randomized prospective study will be needed, with the objective of investigating the role of adjuvant chemotherapy.
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页数:9
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