The peritumoural adipose tissue microenvironment and cancer. The roles of fatty acid binding protein 4 and fatty acid binding protein 5

被引：109

作者：

Guaita-Esteruelas, S. ^{[1
,2
,3
]}

Guma, J. ^{[3
,4
]}

Masana, L. ^{[2
]}

Borras, J. ^{[3
,4
]}

机构：

[1] Inst Invest Sanitaria Pere Virgili, Ctr R D I Nutr & Salut, Avda Univ, Reus 43204, Spain

[2] Univ Rovira & Virgili, Res Unit Lipids & Atherosclerosis, Biomed Res Ctr Diabet & Associated Metab Disorder, St Llorenc 21, Reus 43201, Spain

[3] Univ Rovira & Virgili, IOCS, Hosp Univ St Joan Reus, IISPV, Av Dr,Josep Laporte 2, Reus 43204, Spain

[4] Univ Rovira & Virgili, Dept Med & Surg, St Llorenc 21, Reus 43201, Spain

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2018年 / 462卷

关键词：

Adipose tissue; Cancer associated adipocytes; FABP4; FABP5; Lipid metabolism; TUMOR-ASSOCIATED MACROPHAGES; PROMOTES CELL-PROLIFERATION; BODY-MASS INDEX; BREAST-CANCER; RETINOIC-ACID; PROSTATE-CANCER; ATHEROGENIC DYSLIPIDEMIA; PLASMA FATTY-ACID-BINDING-PROTEIN-4; GEL-ELECTROPHORESIS; INSULIN-RESISTANCE;

D O I：

10.1016/j.mce.2017.02.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The adipose tissue microenvironment plays a key role in tumour initiation and progression because it provides fatty acids and adipokines to tumour cells. The fatty acid-binding protein (FABP) family is a group of small proteins that act as intracellular fatty acid transporters. Adipose-derived FABPs include FABP4 and FABP5. Both have an important role in lipid-related metabolic processes and overexpressed in many cancers, such as breast, prostate, colorectal and ovarian. Moreover, their expression in peritumoural adipose tissue is deregulated, and their circulating levels are upregulated in some tumours. In this review, we discuss the role of the peritumoural adipose tissue and the related adipokines FABP4 and FABP5 in cancer initiation and progression and the possible pathways implicated in these processes. (C)2017 Elsevier B.V. All rights reserved.

引用

页码：107 / 118

页数：12

共 166 条

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