Nd:YAG laser irradiation in conjunction with cryogen spray cooling induces deep and spatially selective photocoagulation in animal models

被引：12
作者：
Anvari, B
Tanenbaum, BS
Hoffman, W
Said, S
Milner, TE
Liaw, LHL
Nelson, JS
机构：
[1] HARVEY MUDD COLL, DEPT ENGN, CLAREMONT, CA 91711 USA
[2] UNIV CALIF IRVINE, SCH MED, DEPT DERMATOL, IRVINE, CA 92717 USA
[3] HARVEY MUDD COLL, DEPT PHYS, CLAREMONT, CA 91711 USA
来源：
PHYSICS IN MEDICINE AND BIOLOGY | 1997年 / 42卷 / 02期
关键词：
D O I：
10.1088/0031-9155/42/2/001
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Successful laser treatment of haemangiomas requires selective photocoagulation of subsurface targeted blood vessels without thermal damage to the overlying epidermis. We present an in vivo experimental procedure, using a chicken comb animal model, and an infrared feedback system to deliver repetitive cryogen spurts (of the order of milliseconds) during continuous Nd:YAG laser irradiation. Gross and histologic observations show deep-tissue photocoagulation is achieved, while superficial structures are protected from thermal injury due to cryogen spray cooling. Experimental observation of epidermis protection in chicken comb animal models suggests selective photocoagulation of subsurface targeted blood vessels for successful treatment of haemangiomas can be achieved by repetitive applications of a cryogen spurt during continuous Nd:YAG laser irradiation.
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收藏
页码：265 / 282
页数：18
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