Tertiary amino thiourea-catalyzed asymmetric cross aldol reaction of aryl methyl ketones with aryl trifluoromethyl ketones

被引：19

作者：

Lutete, Leopold Mpaka ^{[1
]}

Miyamoto, Takashi ^{[1
]}

Ikemoto, Tetsuya ^{[1
]}

机构：

[1] Sumitomo Chem Co Ltd, Hlth & Crop Sci Res Lab, Nishiyodogawa Ku, 1-21 Utajima 3-Chome, Osaka 5550021, Japan

来源：

TETRAHEDRON LETTERS | 2016年 / 57卷 / 11期

关键词：

Aldol reaction; Thiourea; Bifunctional catalyst; Organocatalysis; Trifluoromethyl ketones; ENANTIOSELECTIVE SYNTHESIS; MICHAEL ADDITION; DUAL ACTIVATION; PROLINE; ORGANOCATALYSIS; MECHANISM;

D O I：

10.1016/j.tetlet.2016.02.001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enantioselective aldol reaction of aryl methyl ketones with aryl trifluoromethyl ketones catalyzed by tertiary amino thiourea has been established. Under mild conditions, the corresponding beta-trifluoromethyl-beta-hydroxy ketone products were obtained with up to 89% ee. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：1220 / 1223

页数：4

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