Factors associated with failure to complete adjuvant chemotherapy in pancreatic cancer

被引：31

作者：

Akahori, Takahiro ^{[1
]}

Sho, Masayuki ^{[1
]}

Tanaka, Toshihiro ^{[2
]}

Kinoshita, Shoichi ^{[1
]}

Nagai, Minako ^{[1
]}

Nishiwada, Satoshi ^{[1
]}

Nishiofuku, Hideyuki ^{[2
]}

Ohbayashi, Chiho ^{[3
]}

Kichikawa, Kimihiko ^{[2
]}

Nakajima, Yoshiyuki ^{[1
]}

机构：

[1] Nara Med Univ, Dept Surg, 840 Shijo Cho, Nara 6348522, Japan

[2] Nara Med Univ, Dept Radiol, Nara 6348522, Japan

[3] Nara Med Univ, Dept Diagnost Pathol, Nara 6348522, Japan

来源：

AMERICAN JOURNAL OF SURGERY | 2016年 / 211卷 / 04期

关键词：

Pancreatic cancer; Adjuvant chemotherapy; Prognosis; Recurrence; INTERNATIONAL STUDY-GROUP; SURGERY; PANCREATICODUODENECTOMY; ADENOCARCINOMA; NUTRITION; CHEMORADIATION; GEMCITABINE; RESECTION; FISTULA; IMPACT;

D O I：

10.1016/j.amjsurg.2015.10.034

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

BACKGROUND: The importance of completing adjuvant chemotherapy in pancreatic cancer is becoming recognized. However, the clinicopathological factors associated with failure to complete adjuvant chemotherapy remain unclear. METHODS: A total of 135 patients were analyzed to identify the factors associated with failure to complete adjuvant chemotherapy. RESULTS: Ninety patients completed planned adjuvant chemotherapy, whereas 45 patients failed to complete adjuvant chemotherapy. Lower preoperative prognostic nutritional index, intraoperative blood transfusion, and organ and/or space surgical site infection, and advanced tumor stage were associated with failure to complete adjuvant chemotherapy. Neoadjuvant chemoradiotherapy was associated with significantly lower prognostic nutritional index, less incidence of organ and/or space surgical site infection, and earlier tumor stage, suggesting the conflicting effects of neoadjuvant chemoradiotherapy on completing adjuvant chemotherapy. CONCLUSIONS: Several clinicopathological factors including patient conditions and perioperative events were associated with failure to complete adjuvant chemotherapy. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：787 / 792

页数：6

共 33 条

[1] ESPEN guidelines on enteral nutrition:: Non-surgical oncology [J].

Arends, J. ;

Bodoky, G. ;

Bozzetti, F. ;

Fearon, K. ;

Muscaritoli, M. ;

Selga, G. ;

van Bokhorst-de van der Schuereng, M. A. E. ;

von Meyenfeldt, M. ;

Zuercher, G. ;

Fietkau, R. ;

Aulbert, E. ;

Frick, B. ;

Holm, M. ;

Kneba, M. ;

Mestrom, H. J. ;

Zander, A. .

CLINICAL NUTRITION, 2006, 25 (02) :245-259

[2] Postoperative pancreatic fistula: An international study group (ISGPF) definition [J].

Bassi, C ;

Dervenis, C ;

Butturini, G ;

Fingerhut, A ;

Yeo, C ;

Izbicki, J ;

Neoptolemos, J ;

Sarr, M ;

Traverso, W ;

Buchler, M .

SURGERY, 2005, 138 (01) :8-13

[3] IMPACT OF CANCER, TYPE, SITE, STAGE AND TREATMENT ON THE NUTRITIONAL-STATUS OF PATIENTS [J].

BOZZETTI, F ;

MIGLIAVACCA, S ;

SCOTTI, A ;

BONALUMI, MG ;

SCARPA, D ;

BATICCI, F ;

AMMATUNA, M ;

PUPA, A ;

TERNO, G ;

SEQUEIRA, C ;

MASSERINI, C ;

EMANUELLI, H .

ANNALS OF SURGERY, 1982, 196 (02) :170-179

[4] Effect of neoadjuvant chemoradiation on operative mortality and morbidity for pancreaticoduodenectomy [J].

Cheng, TY ;

Sheth, K ;

White, RR ;

Ueno, T ;

Hung, CF ;

Clary, BM ;

Pappas, TN ;

Tyler, DS .

ANNALS OF SURGICAL ONCOLOGY, 2006, 13 (01) :66-74

[5] The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM [J].

Edge, Stephen B. ;

Compton, Carolyn C. .

ANNALS OF SURGICAL ONCOLOGY, 2010, 17 (06) :1471-1474

[6] Evolution of the Whipple procedure at the Massachusetts General Hospital [J].

Fernandez-del Castillo, Carlos ;

Morales-Oyarvide, Vicente ;

McGrath, Deborah ;

Wargo, Jennifer A. ;

Ferrone, Cristina R. ;

Thayer, Sarah P. ;

Lillemoe, Keith D. ;

Warshaw, Andrew L. .

SURGERY, 2012, 152 (03) :S56-S63

[7] Pancreatic adenocarcinoma: The actual 5-year survivors [J].

Ferrone, Cristina R. ;

Brennan, Murray F. ;

Gonen, Mithat ;

Coit, Daniel G. ;

Fong, Yuman ;

Chung, Sun ;

Tang, Laura ;

Klimstra, David ;

Allen, Peter J. .

JOURNAL OF GASTROINTESTINAL SURGERY, 2008, 12 (04) :701-706

[8]

Festa V, 2013, J PANCREAS, V14, P618, DOI 10.6092/1590-8577/1724

[9] Nutritional predictors of postoperative outcome in pancreatic cancer [J].

Kanda, M. ;

Fujii, T. ;

Kodera, Y. ;

Nagai, S. ;

Takeda, S. ;

Nakao, A. .

BRITISH JOURNAL OF SURGERY, 2011, 98 (02) :268-274

[10] Effect of zinc administration on pancreatic regeneration after 80% pancreatectomy [J].

Kato, K ;

Isaji, S ;

Kawarada, Y ;

Hibasami, H ;

Nakashima, K .

PANCREAS, 1997, 14 (02) :158-165

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