Dyskeratosis Congenita and Corneal Refractive Surgery

被引：3

作者：

Heiland, Madeline B. ^{[4
]}

Moshirfar, Majid ^{[1
,2
,3
]}

Rosen, David B. ^{[4
]}

Ronquillo, Yasmyne C. ^{[3
]}

Hoopes, Phillip C. ^{[3
]}

机构：

[1] Univ Utah, Sch Med, John A Moran Eye Ctr, Dept Ophthalmol & Visual Sci, Salt Lake City, UT 84132 USA

[2] Utah Lions Eye Bank, Murray, UT USA

[3] Hoopes Vis, Hoopes Durrie Rivera Res Ctr, Draper, UT USA

[4] Univ Arizona, Coll Med Phoenix, Phoenix, AZ USA

来源：

OPHTHALMOLOGY AND THERAPY | 2019年 / 8卷 / 03期

关键词：

Bone marrow failure; Cornea refractive surgery; Dyskeratosis congenita; Graft-versus-host disease; Laser in situ keratomileusis (LASIK); Limbal stem cell deficiency; Ocular manifestations of graft-versus-host disease; Photorefractive keratectomy (PRK); Small-incision lenticule extraction (SMILE); Telomeres;

D O I：

10.1007/s40123-019-0200-z

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Dyskeratosis congenita is a syndrome of bone marrow failure secondary to unstable telomeres. It is characterized by a range of mucocutaneous diseases. Due to premature telomere shortening, these patients have limbal stem cell deficiency leading to poor regeneration and maintenance of the cornea. Many of these patients will require hematopoietic stem cell transplant in their lifetime, which poses a significant risk for acute and chronic graft-versus-host disease with and without ocular manifestations. We advise against elective corneal refractive surgery in patients with dyskeratosis congenita due to the compounded and long-term risks of delayed healing secondary to limbal stem cell deficiency and ocular complications of graft-versus-host disease post-allogeneic hematopoietic stem cell transplant.

引用

页码：361 / 365

页数：5

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