Hemoglobin Target and Transfusion Modality for Adult Patients With Sickle Cell Disease Acute Chest Syndrome
被引:1
作者:
Simonson, Joseph L.
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机构:
Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Med, Div Pulm Crit Care & Sleep Med, Hempstead, NY USADonald & Barbara Zucker Sch Med Hofstra Northwell, Dept Med, Div Pulm Crit Care & Sleep Med, Hempstead, NY USA
Simonson, Joseph L.
[1
]
Rosentsveyg, Juliana A.
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机构:
Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Med, Div Pulm Crit Care & Sleep Med, Hempstead, NY USADonald & Barbara Zucker Sch Med Hofstra Northwell, Dept Med, Div Pulm Crit Care & Sleep Med, Hempstead, NY USA
Rosentsveyg, Juliana A.
[1
]
Schwartz, Noah G.
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h-index: 0
机构:
Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USADonald & Barbara Zucker Sch Med Hofstra Northwell, Dept Med, Div Pulm Crit Care & Sleep Med, Hempstead, NY USA
Schwartz, Noah G.
[2
]
Agrawal, Abhinav
论文数: 0引用数: 0
h-index: 0
机构:
Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Med, Div Pulm Crit Care & Sleep Med, Hempstead, NY USADonald & Barbara Zucker Sch Med Hofstra Northwell, Dept Med, Div Pulm Crit Care & Sleep Med, Hempstead, NY USA
Agrawal, Abhinav
[1
]
Koenig, Seth
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h-index: 0
机构:
Montefiore Med Ctr, Dept Med, Div Pulm Med, Bronx, NY 10467 USADonald & Barbara Zucker Sch Med Hofstra Northwell, Dept Med, Div Pulm Crit Care & Sleep Med, Hempstead, NY USA
Koenig, Seth
[3
]
Zaidi, Gulrukh Z.
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h-index: 0
机构:
Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Med, Div Pulm Crit Care & Sleep Med, Hempstead, NY USADonald & Barbara Zucker Sch Med Hofstra Northwell, Dept Med, Div Pulm Crit Care & Sleep Med, Hempstead, NY USA
Zaidi, Gulrukh Z.
[1
]
机构:
[1] Donald & Barbara Zucker Sch Med Hofstra Northwell, Dept Med, Div Pulm Crit Care & Sleep Med, Hempstead, NY USA
[2] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA
[3] Montefiore Med Ctr, Dept Med, Div Pulm Med, Bronx, NY 10467 USA
Background: Despite the importance of transfusion in treating sickle cell disease acute chest syndrome, the target hemoglobin and optimal modality for transfusion remain unknown. Objectives: To compare hospital length of stay (LOS) in intensive care unit (ICU) patients with acute chest syndrome transfused to hemoglobin >= 8 g/dL versus patients transfused to hemoglobin < 8 g/dL; and to compare hospital LOS in acute chest syndrome patients treated with and without exchange transfusion. Methods: We performed a retrospective cohort study of all acute chest syndrome patients treated in the medical ICU at 2 tertiary care hospitals between January 2011 and August 2016 (n = 82). We compared median hospital LOS in patients transfused to hemoglobin >= 8 g/dL by the time of ICU transfer to the medical floor versus patients transfused to hemoglobin < 8 g/dL as well as patients who received exchange transfusion versus no exchange transfusion using Wilcoxon rank-sum tests. We modeled the association between hospital LOS and hemoglobin at ICU transfer to the medical floor using multivariable log-linear regression. Results: Median hospital LOS was about half as long for patients transfused to hemoglobin >= 8 g/dL versus hemoglobin < 8 g/dL (8.0 versus 16.5 days, P = 0.008). There was no difference in LOS for patients treated with and without exchange transfusion. On average, a 1 g/dL increase in hemoglobin was associated with a 19.5% decrease (95% CI 10.8-28.2%) in LOS, controlling for possible confounding factors. Conclusions: Transfusion to a hemoglobin target >= 8 g/dL is associated with decreased hospital LOS in patients with acute chest syndrome. There was no difference in LOS between patients who received exchange transfusion and those who did not.
机构:
Hop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Winchenne, Anais
Cecchini, Jerome
论文数: 0引用数: 0
h-index: 0
机构:
Hop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Univ Paris Est Creteil, Inst Mondor Rech Biomed, Grp Rech Clin CAR MAS, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Cecchini, Jerome
Deux, Jean-Francois
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h-index: 0
机构:
Hop Univ Henri Mondor, AP HP, Serv Imagerie Med, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Deux, Jean-Francois
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De Prost, Nicolas
Razazi, Keyvan
论文数: 0引用数: 0
h-index: 0
机构:
Hop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Univ Paris Est Creteil, Inst Mondor Rech Biomed, Grp Rech Clin CAR MAS, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Razazi, Keyvan
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Carteaux, Guillaume
Galacteros, Frederic
论文数: 0引用数: 0
h-index: 0
机构:
Hop Univ Henri Mondor, AP HP, Ctr Reference Pathol Globule Rouge, Creteil, France
INSERM, U955, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Galacteros, Frederic
Habibi, Anoosha
论文数: 0引用数: 0
h-index: 0
机构:
Hop Univ Henri Mondor, AP HP, Ctr Reference Pathol Globule Rouge, Creteil, France
INSERM, U955, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Habibi, Anoosha
Bartolucci, Pablo
论文数: 0引用数: 0
h-index: 0
机构:
Hop Univ Henri Mondor, AP HP, Ctr Reference Pathol Globule Rouge, Creteil, France
INSERM, U955, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Bartolucci, Pablo
Melica, Giovanna
论文数: 0引用数: 0
h-index: 0
机构:
Hop Univ Henri Mondor, AP HP, Serv Immunol Clin, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Melica, Giovanna
Khellaf, Mehdi
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U955, Creteil, France
Hop Univ Henri Mondor, AP HP, Serv Urgences, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Khellaf, Mehdi
Michel, Marc
论文数: 0引用数: 0
h-index: 0
机构:
Hop Univ Henri Mondor, AP HP, Serv Med Interne, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Michel, Marc
Maitre, Bernard
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Est Creteil, Inst Mondor Rech Biomed, Grp Rech Clin CAR MAS, Creteil, France
Hop Univ Henri Mondor, AP HP, Unite Pneumol, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Maitre, Bernard
Dessap, Armand Mekontso
论文数: 0引用数: 0
h-index: 0
机构:
Hop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Univ Paris Est Creteil, Inst Mondor Rech Biomed, Grp Rech Clin CAR MAS, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
机构:
Hop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
CHU Poitiers, Serv Reanimat Med, Poitiers, France
Univ Poitiers, INSERM CIC 1402, ALIVE Grp, Poitiers, FranceHop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
Boissier, Florence
Bagate, Francois
论文数: 0引用数: 0
h-index: 0
机构:
Hop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
Univ Paris Est Creteil, GRC CARMAS, IMRB, Fac Med Creteil, Creteil, FranceHop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
Bagate, Francois
Schmidt, Matthieu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, Med Intens Care Unit, ICAN, Inst Cardiometab & Nutr,Hop Pitie Salpetriere,AP, Paris, FranceHop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
Schmidt, Matthieu
Labbe, Vincent
论文数: 0引用数: 0
h-index: 0
机构:
Hop Tenon, AP HP, Serv Reanimat Polyvalente, Paris, France
UPMC Univ Paris 6, Paris, FranceHop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
Labbe, Vincent
Kimmoun, Antoine
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h-index: 0
机构:
CHRU Nancy, Serv Reanimat & Med Intens Brabois, Inst Louis Mathieu, Vandoeuvre Les Nancy, FranceHop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
Kimmoun, Antoine
Fartoukh, Muriel
论文数: 0引用数: 0
h-index: 0
机构:
Hop Tenon, AP HP, Serv Reanimat Polyvalente, Paris, France
UPMC Univ Paris 6, Paris, FranceHop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
Fartoukh, Muriel
Dessap, Armand Mekontso
论文数: 0引用数: 0
h-index: 0
机构:
Hop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
Univ Paris Est Creteil, GRC CARMAS, IMRB, Fac Med Creteil, Creteil, FranceHop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
机构:
Hop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Winchenne, Anais
Cecchini, Jerome
论文数: 0引用数: 0
h-index: 0
机构:
Hop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Univ Paris Est Creteil, Inst Mondor Rech Biomed, Grp Rech Clin CAR MAS, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Cecchini, Jerome
Deux, Jean-Francois
论文数: 0引用数: 0
h-index: 0
机构:
Hop Univ Henri Mondor, AP HP, Serv Imagerie Med, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Deux, Jean-Francois
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h-index:
机构:
De Prost, Nicolas
Razazi, Keyvan
论文数: 0引用数: 0
h-index: 0
机构:
Hop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Univ Paris Est Creteil, Inst Mondor Rech Biomed, Grp Rech Clin CAR MAS, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Razazi, Keyvan
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机构:
Carteaux, Guillaume
Galacteros, Frederic
论文数: 0引用数: 0
h-index: 0
机构:
Hop Univ Henri Mondor, AP HP, Ctr Reference Pathol Globule Rouge, Creteil, France
INSERM, U955, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Galacteros, Frederic
Habibi, Anoosha
论文数: 0引用数: 0
h-index: 0
机构:
Hop Univ Henri Mondor, AP HP, Ctr Reference Pathol Globule Rouge, Creteil, France
INSERM, U955, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Habibi, Anoosha
Bartolucci, Pablo
论文数: 0引用数: 0
h-index: 0
机构:
Hop Univ Henri Mondor, AP HP, Ctr Reference Pathol Globule Rouge, Creteil, France
INSERM, U955, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Bartolucci, Pablo
Melica, Giovanna
论文数: 0引用数: 0
h-index: 0
机构:
Hop Univ Henri Mondor, AP HP, Serv Immunol Clin, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Melica, Giovanna
Khellaf, Mehdi
论文数: 0引用数: 0
h-index: 0
机构:
INSERM, U955, Creteil, France
Hop Univ Henri Mondor, AP HP, Serv Urgences, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Khellaf, Mehdi
Michel, Marc
论文数: 0引用数: 0
h-index: 0
机构:
Hop Univ Henri Mondor, AP HP, Serv Med Interne, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Michel, Marc
Maitre, Bernard
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris Est Creteil, Inst Mondor Rech Biomed, Grp Rech Clin CAR MAS, Creteil, France
Hop Univ Henri Mondor, AP HP, Unite Pneumol, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Maitre, Bernard
Dessap, Armand Mekontso
论文数: 0引用数: 0
h-index: 0
机构:
Hop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
Univ Paris Est Creteil, Inst Mondor Rech Biomed, Grp Rech Clin CAR MAS, Creteil, FranceHop Univ Henri Mondor, AP HP, Serv Reanimat Med, Creteil, France
机构:
Hop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
CHU Poitiers, Serv Reanimat Med, Poitiers, France
Univ Poitiers, INSERM CIC 1402, ALIVE Grp, Poitiers, FranceHop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
Boissier, Florence
Bagate, Francois
论文数: 0引用数: 0
h-index: 0
机构:
Hop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
Univ Paris Est Creteil, GRC CARMAS, IMRB, Fac Med Creteil, Creteil, FranceHop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
Bagate, Francois
Schmidt, Matthieu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 06, Med Intens Care Unit, ICAN, Inst Cardiometab & Nutr,Hop Pitie Salpetriere,AP, Paris, FranceHop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
Schmidt, Matthieu
Labbe, Vincent
论文数: 0引用数: 0
h-index: 0
机构:
Hop Tenon, AP HP, Serv Reanimat Polyvalente, Paris, France
UPMC Univ Paris 6, Paris, FranceHop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
Labbe, Vincent
Kimmoun, Antoine
论文数: 0引用数: 0
h-index: 0
机构:
CHRU Nancy, Serv Reanimat & Med Intens Brabois, Inst Louis Mathieu, Vandoeuvre Les Nancy, FranceHop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
Kimmoun, Antoine
Fartoukh, Muriel
论文数: 0引用数: 0
h-index: 0
机构:
Hop Tenon, AP HP, Serv Reanimat Polyvalente, Paris, France
UPMC Univ Paris 6, Paris, FranceHop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
Fartoukh, Muriel
Dessap, Armand Mekontso
论文数: 0引用数: 0
h-index: 0
机构:
Hop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France
Univ Paris Est Creteil, GRC CARMAS, IMRB, Fac Med Creteil, Creteil, FranceHop Henri Mondor, AP HP, Serv Reanimat Med, DHU A TVB, Creteil, France