Epstein Barr Virus and Autoimmune Responses in Systemic Lupus Erythematosus

被引：97
作者：
Jog, Neelakshi R. [1 ]
James, Judith A. [1 ,2 ,3 ,4 ]
机构：
[1] Oklahoma Med Res Fdn, Arthrit & Clin Immunol, 825 NE 13th St, Oklahoma City, OK 73104 USA
[2] Univ Oklahoma, Hlth Sci Ctr, Dept Med, Oklahoma City, OK USA
[3] Univ Oklahoma, Hlth Sci Ctr, Dept Pathol, Oklahoma City, OK USA
[4] Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, Oklahoma City, OK 73190 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2021年 / 11卷
关键词：
Epstein-Barr virus; systemic lupus erythematosus; inflammation; autoimmune disease; viral homologs of host genes; molecular mimicry;
D O I：
10.3389/fimmu.2020.623944
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease. Infections or infectious reactivation are potential triggers for initiation of autoimmunity and for SLE flares. Epstein-Barr virus (EBV) is gamma herpes virus that has been associated with several autoimmune diseases such as SLE, multiple sclerosis, Sjogren's syndrome, and systemic sclerosis. In this review, we will discuss the recent advances regarding how EBV may contribute to immune dysregulation, and how these mechanisms may relate to SLE disease progression.
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页数：11
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