Dendritic cell immunotherapy for autoimmune diabetes

被引：11

作者：

Feili-Hariri, Maryam

Flores, Rafael R.

Vasquez, A. Cecilia

Morel, Penelope A.

机构：

[1] Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Dept Immunol, Pittsburgh, PA 15261 USA

来源：

IMMUNOLOGIC RESEARCH | 2006年 / 36卷 / 1-3期

关键词：

dendritic cells; type; 1; diabetes; autoimmunity; immunotherapy;

D O I：

10.1385/IR:36:1:167

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DC) play important roles in the initiation of immune responses and maintenance of self-tolerance. We have been studying the role of DC in the pathogenesis of type I diabetes and exploring the ability of specific DC subsets to prevent diabetes in non-obese diabetic (NOD) mice. DC subsets that prevent diabetes in this model have a mature phenotype and induce the production of regulatory Th2 cells. We review here recent advances in this area and highlight the importance of optimizing culture conditions and purification methods in the isolation of therapeutic DC.

引用

收藏

页码：167 / 173

页数：7

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