Dendritic cell immunotherapy for autoimmune diabetes

被引：11
作者：
Feili-Hariri, Maryam
Flores, Rafael R.
Vasquez, A. Cecilia
Morel, Penelope A.
机构：
[1] Univ Pittsburgh, Dept Surg, Pittsburgh, PA 15261 USA
[2] Univ Pittsburgh, Dept Immunol, Pittsburgh, PA 15261 USA
来源：
IMMUNOLOGIC RESEARCH | 2006年 / 36卷 / 1-3期
关键词：
dendritic cells; type; 1; diabetes; autoimmunity; immunotherapy;
D O I：
10.1385/IR:36:1:167
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Dendritic cells (DC) play important roles in the initiation of immune responses and maintenance of self-tolerance. We have been studying the role of DC in the pathogenesis of type I diabetes and exploring the ability of specific DC subsets to prevent diabetes in non-obese diabetic (NOD) mice. DC subsets that prevent diabetes in this model have a mature phenotype and induce the production of regulatory Th2 cells. We review here recent advances in this area and highlight the importance of optimizing culture conditions and purification methods in the isolation of therapeutic DC.
引用
收藏
页码：167 / 173
页数：7
相关论文
共 37 条
[1]   Association between alpha beta TCR(+)CD4(-)CD8(-) T-cell deficiency and IDDM in NOD/Lt mice [J].
Baxter, AG ;
Kinder, SJ ;
Hammond, KJL ;
Scollay, R ;
Godfrey, DI .
DIABETES, 1997, 46 (04) :572-582
[2]  
CASTANO L, 1990, ANNU REV IMMUNOL, V8, P647, DOI 10.1146/annurev.iy.08.040190.003243
[3]   Suppressor T cells - they're back and critical for regulation of autoimmunity! [J].
Chatenoud, L ;
Salomon, B ;
Bluestone, JA .
IMMUNOLOGICAL REVIEWS, 2001, 182 :149-163
[4]   ADOPTIVE TRANSFER OF DIABETES INTO IMMUNODEFICIENT NOD-SCID SCID MICE - RELATIVE CONTRIBUTIONS OF CD4+ AND CD8+ T-CELLS FROM DIABETIC VERSUS PREDIABETIC NOD.NON-THY-1A DONORS [J].
CHRISTIANSON, SW ;
SHULTZ, LD ;
LEITER, EH .
DIABETES, 1993, 42 (01) :44-55
[5]   Polarization of naive T cells into Th1 or Th2 by distinct cytokine-driven murine dendritic cell populations: implications for immunotherapy [J].
Feili-Hariri, M ;
Falkner, DH ;
Morel, PA .
JOURNAL OF LEUKOCYTE BIOLOGY, 2005, 78 (03) :656-664
[6]   Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis [J].
Feili-Hariri, M ;
Falkner, DH ;
Gambotto, A ;
Papworth, GD ;
Watkins, SC ;
Robbins, PD ;
Morel, PA .
HUMAN GENE THERAPY, 2003, 14 (01) :13-23
[7]  
Feili-Hariri M, 2002, EUR J IMMUNOL, V32, P2021, DOI 10.1002/1521-4141(200207)32:7<2021::AID-IMMU2021>3.0.CO
[8]  
2-J
[9]   Phenotypic and functional characteristics of BM-derived DC from NOD and non-diabetes-prone strains [J].
Feili-Hariri, M ;
Morel, PA .
CLINICAL IMMUNOLOGY, 2001, 98 (01) :133-142
[10]   Immunotherapy of NOD mice with bone marrow-derived dendritic cells [J].
Feili-Hariri, M ;
Dong, X ;
Alber, SM ;
Watkins, SC ;
Salter, RD ;
Morel, PA .
DIABETES, 1999, 48 (12) :2300-2308
1234