Targeting DNA Repair and Chromatin Crosstalk in Cancer Therapy

被引：3

作者：

Johnson, Danielle P. ^{[1
]}

Chandrasekharan, Mahesh B. ^{[1
]}

Dutreix, Marie ^{[2
]}

Bhaskara, Srividya ^{[1
]}

机构：

[1] Univ Utah, Huntsman Canc Inst, Sch Med, Salt Lake City, UT 84112 USA

[2] Inst Curie, Univ Ctr, INSERM, CNRS, F-91405 Orsay, France

来源：

CANCERS | 2021年 / 13卷 / 03期

关键词：

DNA repair; cancer therapy; repair inhibition; histone deacetylases;

D O I：

10.3390/cancers13030381

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Simple Summary Targeting aberrant DNA repair in cancers in addition to transcription and replication is an area of interest for cancer researchers. Inhibition of DNA repair selectively in cancer cells leads to cytotoxic or cytostatic effects and overcomes survival advantages imparted by chromosomal translocations or mutations. In this review, we highlight the relevance of DNA repair-linked events in developmental diseases and cancers and also discuss mechanisms to overcome these events that participate in different cellular processes. Aberrant DNA repair pathways that underlie developmental diseases and cancers are potential targets for therapeutic intervention. Targeting DNA repair signal effectors, modulators and checkpoint proteins, and utilizing the synthetic lethality phenomena has led to seminal discoveries. Efforts to efficiently translate the basic findings to the clinic are currently underway. Chromatin modulation is an integral part of DNA repair cascades and an emerging field of investigation. Here, we discuss some of the key advancements made in DNA repair-based therapeutics and what is known regarding crosstalk between chromatin and repair pathways during various cellular processes, with an emphasis on cancer.

引用

页码：1 / 14

页数：14

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