TTC3 Ubiquitination Terminates Akt-ivation

被引：12

作者：

Toker, Alex ^{[1
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Pathol, Boston, MA 02215 USA

来源：

DEVELOPMENTAL CELL | 2009年 / 17卷 / 06期

关键词：

APOPTOSIS; CANCER;

D O I：

10.1016/j.devcel.2009.12.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this issue off Developmental Cell, Suizu et al. (2009) describe a new mechanism for posttranslational regulation of the Akt serine/threonine protein kinase involving ubiquitination. They show that the E3 ubiquitin ligase TTC3 modifies phosphorylated and activated Akt and thereby promotes its degradation by the proteasome in the nucleus.

引用

页码：752 / 754

页数：3

共 10 条

[1] Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer [J].

Chin, Y. Rebecca ;

Toker, Alex .

CELLULAR SIGNALLING, 2009, 21 (04) :470-476

[2] Targeting PI3K signalling in cancer: opportunities, challenges and limitations [J].

Engelman, Jeffrey A. .

NATURE REVIEWS CANCER, 2009, 9 (08) :550-562

[3] The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C [J].

Facchinetti, Valeria ;

Ouyang, Weiming ;

Wei, Hua ;

Soto, Nelyn ;

Lazorchak, Adam ;

Gould, Christine ;

Lowry, Carolyn ;

Newton, Alexandra C. ;

Mao, Yuxin ;

Miao, Robert Q. ;

Sessa, William C. ;

Qin, Jun ;

Zhang, Pumin ;

Su, Bing ;

Jacinto, Estela .

EMBO JOURNAL, 2008, 27 (14) :1932-1943

[4] PHLPP: A phosphatase that directly dephosphorylates akt, promotes apoptosis, and suppresses tumor growth [J].

Gao, TY ;

Furnari, F ;

Newton, AC .

MOLECULAR CELL, 2005, 18 (01) :13-24

[5] The role of PTEN signaling perturbations in cancer and in targeted therapy [J].

Keniry, M. ;

Parsons, R. .

ONCOGENE, 2008, 27 (41) :5477-5485

[6] AKT/PKB signaling: Navigating downstream [J].

Manning, Brendan D. ;

Cantley, Lewis C. .

CELL, 2007, 129 (07) :1261-1274

[7] Intranuclear 3′-phosphoinositide metabolism and Akt signaling:: New mechanisms for tumorigenesis and protection against apoptosis? [J].

Martelli, Alberto M. ;

Faenza, Irene ;

Billi, Anna Maria ;

Manzoli, Lucia ;

Evangelisti, Camilla ;

Fala, Federica ;

Cocco, Lucio .

CELLULAR SIGNALLING, 2006, 18 (08) :1101-1107

[8] The E3 Ligase TTC3 Facilitates Ubiquitination and Degradation of Phosphorylated Akt [J].

Suizu, Futoshi ;

Hiramuki, Yosuke ;

Okumura, Fumihiko ;

Matsuda, Mami ;

Okumura, Akiko J. ;

Hirata, Noriyuki ;

Narita, Masumi ;

Kohno, Takashi ;

Yokota, Jun ;

Bohgaki, Miyuki ;

Obuse, Chikashi ;

Hatakeyama, Shigetsugu ;

Obata, Toshiyuki ;

Noguchi, Masayuki .

DEVELOPMENTAL CELL, 2009, 17 (06) :800-810

[9] The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation [J].

Yang, Wei-Lei ;

Wang, Jing ;

Chan, Chia-Hsin ;

Lee, Szu-Wei ;

Campos, Alejandro D. ;

Lamothe, Betty ;

Hur, Lana ;

Grabiner, Brian C. ;

Lin, Xin ;

Darnay, Bryant G. ;

Lin, Hui-Kuan .

SCIENCE, 2009, 325 (5944) :1134-1138

[10] S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt [J].

Zhang, Hui H. ;

Lipovsky, Alex I. ;

Dibble, Christian C. ;

Sahin, Mustafa ;

Manning, Brendan D. .

MOLECULAR CELL, 2006, 24 (02) :185-197

← 1 →