SYNPHOS®, a new chiral diphosphine ligand:: synthesis, molecular modeling and application in asymmetric hydrogenation

被引：0
作者：
de Paule, SD
Jeulin, S
Ratovelomanana-Vidal, V
Genêt, JP
Champion, N
Dellis, P
机构：
[1] Lab Synth Select Organ & Prod Nat, UMR 7573, Paris, France
[2] SYNKEM SAS, Chenove, France
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 04期
关键词：
diphosphine ligand; molecular modeling; asymmetric hydrogenation; ruthenium;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new optically active diphosphine ligand, [(5,6),(5',6')-bis(ethylenedioxy)biphenyl-2,2'-diyl]bis(diphenylphosphine) (SYNPHOS(R)) has been synthesized and used in ruthenium-catalyzed asymmetric hydrogenation. This new ligand has been compared to other diphosphines (BINAP and MeO-BIPHEP), regarding their dihedral angles and the enantioselectivity in the ruthenium mediated hydrogenation reaction. (C) 2003 Elsevier Science Ltd. All rights reserved.
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页码：823 / 826
页数：4
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