The Effect of Interleukin 38 on Angiogenesis in a Model of Oxygen-induced Retinopathy

被引：22

作者：

Zhang, Jing ^{[1
]}

Zhao, Ruijuan ^{[1
]}

Chen, Jianping ^{[1
]}

Jin, Jiayi ^{[1
]}

Yu, Ying ^{[1
]}

Tian, Yunzhe ^{[1
]}

Li, Weihua ^{[1
]}

Wang, Wencong ^{[1
]}

Zhou, Hongyan ^{[1
]}

Su, Shao Bo ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Zhongshan Ophthalm Ctr, State Key Lab Ophthalmol, Guangzhou 510060, Guangdong, Peoples R China

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

基金：

中国国家自然科学基金;

关键词：

GENE-COMPLEX MEMBERS; ANKYLOSING-SPONDYLITIS; IN-VITRO; NEOVASCULARIZATION; ASSOCIATION; MECHANISMS; CLUSTER; CELLS; IL-1; IDENTIFICATION;

D O I：

10.1038/s41598-017-03079-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Interleukin 38 (IL-38) is a novel identified cytokine of IL-1 family in which some members are important in inflammation and angiogenesis. However, the role of IL-38 in regulating angiogenesis is unknown. The aim of the present study is to explore the effect of IL-38 on angiogenesis. Oxygen-induced retinopathy (OIR) of C57BL/6 J mice was induced by exposure of hyperoxia (75% oxygen) from postnatal day 7 (P7) to P12 and then returned to room air. The mice were injected with IL-38. At P17, neovascular region (tufts) and avascular area of the retinas were analyzed. The data showed that administration of IL-38 in vivo inhibited retinal angiogenesis significantly. Furthermore, the addition of IL-38 to the cell cultures attenuated the proliferation, scratch wound healing and tube formation of vascular endothelial cells induced by VEGF significantly. Our findings suggest that IL-38 is an antiangiogenic cytokine in pathophysiological settings and may have therapeutic potential for angiogenesis related diseases.

引用

页数：9

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