Fibroblast-myocyte coupling in the heart: Potential relevance for therapeutic interventions

被引：73

作者：

Ongstad, Emily ^{[1
,2
]}

Kohl, Peter ^{[3
,4
]}

机构：

[1] Clemson Univ, Dept Bioengn, Clemson, SC USA

[2] Virginia Tech Caril Res Inst, Roanoke, VA 24016 USA

[3] Univ Freiburg, Fac Med, Univ Heart Ctr Freiburg Bad Krozingen, Inst Expt Cardiovasc Med, Freiburg, Germany

[4] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Cardiac Biophys & Syst Biol, London SW7 2AZ, England

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2016年 / 91卷

基金：

英国生物技术与生命科学研究理事会; 欧洲研究理事会;

关键词：

Scar; Gap junction; Cardiac electrophysiology; MARROW-DERIVED CELLS; MECHANICALLY INDUCED POTENTIALS; RAT CARDIAC FIBROBLASTS; IN-VIVO; MYOCARDIAL-INFARCTION; ACTIVATION PROTEIN; ATRIAL FIBROBLASTS; VENTRICULAR FIBROBLASTS; REMODELING INTERFACE; SPATIAL-DISTRIBUTION;

D O I：

10.1016/j.yjmcc.2016.01.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiac myocyte-fibroblast electrotonic coupling is a well-established fact in vitro. Indirect evidence of its presence in vivo exists, but few functional studies have been published. This review describes the current knowledge of fibroblast-myocyte electrical signaling in the heart. Further research is needed to understand the frequency and extent of heterocellular interactions in vivo in order to gain a better understanding of their relevance in healthy and diseased myocardium. It is hoped that associated insight into myocyte-fibroblast coupling in the heart may lead to the discovery of novel therapeutic targets and the development of agents for improving outcomes of myocardial scarring and fibrosis. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：238 / 246

页数：9

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