O2 sensing, mitochondria and ROS signaling: The fog is lifting

被引：150

作者：

Waypa, Gregory B. ^{[1
]}

Smith, Kimberly A. ^{[1
]}

Schumacker, Paul T. ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Div Neonatol, Dept Pediat, 320 E Super St,Morton Bldg 4-685, Chicago, IL 60611 USA

来源：

MOLECULAR ASPECTS OF MEDICINE | 2016年 / 47-48卷

关键词：

Hypoxia; electron transport chain; oxidant signaling; metabolism; HYPOXIA-INDUCIBLE-FACTOR; PULMONARY VASCULAR REACTIVITY; HYDROGEN-PEROXIDE GENERATION; OXYGEN SPECIES GENERATION; ELECTRON-TRANSPORT CHAIN; SMOOTH-MUSCLE-CELLS; COMPLEX-III; CAROTID-BODY; MICE LACKING; HIF-ALPHA;

D O I：

10.1016/j.mam.2016.01.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria are responsible for the majority of oxygen consumption in cells, and thus represent a conceptually appealing site for cellular oxygen sensing. Over the past 40 years, a number of mechanisms to explain how mitochondria participate in oxygen sensing have been proposed. However, no consensus has been reached regarding how mitochondria could regulate transcriptional and post-translational responses to hypoxia. Nevertheless, a growing body of data continues to implicate a role for increased reactive oxygen species (ROS) signals from the electron transport chain (ETC) in triggering responses to hypoxia in diverse cell types. The present article reviews our progress in understanding this field and considers recent advances that provide new insight, helping to lift the fog from this complex topic. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：76 / 89

页数：14

共 147 条

[1]

AMBROSIO G, 1993, J BIOL CHEM, V268, P18532

[2] The mechanism(s) of hypoxic pulmonary vasoconstriction:: Potassium channels, redox O2 sensors, and controversies [J].

Archer, S ;

Michelakis, E .

NEWS IN PHYSIOLOGICAL SCIENCES, 2002, 17 :131-137

[3] DETECTION OF ACTIVATED O-2 SPECIES INVITRO AND IN RAT LUNGS BY CHEMI-LUMINESCENCE [J].

ARCHER, SL ;

NELSON, DP ;

WEIR, EK .

JOURNAL OF APPLIED PHYSIOLOGY, 1989, 67 (05) :1912-1921

[4] SIMULTANEOUS MEASUREMENT OF O-2 RADICALS AND PULMONARY VASCULAR REACTIVITY IN RAT LUNG [J].

ARCHER, SL ;

NELSON, DP ;

WEIR, EK .

JOURNAL OF APPLIED PHYSIOLOGY, 1989, 67 (05) :1903-1911

[5] O2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase [J].

Archer, SL ;

Reeve, HL ;

Michelakis, E ;

Puttagunta, L ;

Waite, R ;

Nelson, DP ;

Dinauer, MC ;

Weir, EK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (14) :7944-7949

[6] OXYGEN RADICALS AND ANTIOXIDANT ENZYMES ALTER PULMONARY VASCULAR REACTIVITY IN THE RAT LUNG [J].

ARCHER, SL ;

PETERSON, D ;

NELSON, DP ;

DEMASTER, EG ;

KELLY, B ;

EATON, JW ;

WEIR, EK .

JOURNAL OF APPLIED PHYSIOLOGY, 1989, 66 (01) :102-111

[7] Mitochondrial metabolism, redox signaling, and fusion:: a mitochondria-ROS-HIF-1α-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer [J].

Archer, Stephen L. ;

Gomberg-Maitland, Mardi ;

Maitland, Michael L. ;

Rich, Stuart ;

Garcia, Joe G. N. ;

Weir, E. Kenneth .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2008, 294 (02) :H570-H578

[8]

Archer Stephen L, 2006, Novartis Found Symp, V272, P157

[9] Two redox centers within Yap1 for H2O2 and thiol-reactive chemicals signaling [J].

Azevedo, D ;

Tacnet, F ;

Delaunay, A ;

Rodrigues-Pousada, C ;

Toledano, MB .

FREE RADICAL BIOLOGY AND MEDICINE, 2003, 35 (08) :889-900

[10] Regulation of reactive oxygen species generation in cell signaling [J].

Bae, Yun Soo ;

Oh, Hyunjin ;

Rhee, Sue Goo ;

Do Yoo, Young .

MOLECULES AND CELLS, 2011, 32 (06) :491-509

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