Facile Synthesis of Polycyclic Fluorene Derivatives via a Palladium-Catalyzed Coupling, Propargyl-Allenyl Isomerization and Schmittel Cyclization Sequence

被引：28

作者：

Shen, Ruwei ^{[1
]}

Chen, Linzhu ^{[1
]}

Huang, Xian ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310028, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2009年 / 351卷 / 17期

基金：

中国国家自然科学基金;

关键词：

allenes; fluorenes; Schmittel cyclization; sequential reactions; FORMAL DIELS-ALDER; ENYNE-ALLENES; MYERS-SAITO; C-2-C-6; CYCLIZATION; DOMINO REACTIONS; BIRADICAL CYCLIZATION; NATURAL-PRODUCTS; TANDEM REACTIONS; ENE REACTION; SWITCH;

D O I：

10.1002/adsc.200900600

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A stepwise process involving Sonogashira coupling, propargyl-allenyl isomerization and Schmittel cyclization has been realized, leading to an efficient synthesis of polycyclic fluorene derivatives from readily available starting materials. The reaction features the formation of three new carbon-carbon bonds to construct the benzene unit together with an efficient assembly of three or four rings in a single operative step.

引用

页码：2833 / 2838

页数：6

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