Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain

被引：22

作者：

Fernandez de Larrea-Baz, Nerea ^{[1
,2
]}

Michel, Angelika ^{[3
]}

Romero, Beatriz

Perez-Gomez, Beatriz ^{[1
,4
,5
]}

Moreno, Victor ^{[6
,7
,8
]}

Martin, Vicente ^{[9
,10
]}

Dierssen-Sotos, Trinidad ^{[2
,11
]}

Jimenez-Moleon, Jose J. ^{[2
,12
,13
]}

Castilla, Jesus ^{[2
,14
]}

Tardon, Adonina ^{[2
,15
]}

Ruiz, Irune ^{[16
]}

Peiro, Rosana ^{[2
,17
]}

Tejada, Antonio ^{[18
]}

Chirlaque, Maria D. ^{[2
,19
,20
]}

Butt, Julia A. ^{[3
]}

Olmedo-Requena, Rocio ^{[2
,12
,13
]}

Gomez-Acebo, Ines ^{[2
]}

Linares, Pedro ^{[21
]}

Boldo, Elena ^{[2
,5
]}

Castells, Antoni ^{[22
,23
,24
,25
]}

Pawlita, Michael ^{[3
]}

Castano-Vinyals, Gemma ^{[2
,26
,27
,28
]}

Kogevinas, Manolis ^{[2
,26
,27
,28
]}

de Sanjose, Silvia ^{[2
,29
]}

Pollan, Marina ^{[2
,5
]}

del Campo, Rosa ^{[4
,30
]}

Waterboer, Tim ^{[3
]}

Aragones, Nuria ^{[1
,2
]}

机构：

[1] Inst Salud Carlos III, Area Natl Ctr Epidemiol, Environm & Canc Epidemiol Area, Madrid, Spain

[2] CIBERESP, CIBER Epidemiol & Publ Hlth, Consortium Biomed Res Epidemiol & Publ Hlth, Madrid, Spain

[3] German Canc Res Ctr, Div Mol Diagnost Oncogen Infect Infect Inflammat, Heidelberg, Germany

[4] Ramon & Cajal Univ Hosp IRYCIS, Dept Microbiol, Madrid, Spain

[5] IIS Puerta Hierro, Puerta Hierro Hlth Res Inst, Canc Epidemiol Res Grp Oncol & Hematol Area, Madrid, Spain

[6] Hosp Llobregat, Catalan Inst Oncol, Canc Prevent & Control Program, Barcelona, Spain

[7] Univ Barcelona, Fac Med, Dept Clin Sci, Barcelona, Spain

[8] Hosp Llobregat, Bellvitge Biomed Res Inst IDIBELL, Colorectal Canc Grp, Barcelona, Spain

[9] Univ Leon, Res Grp Gene Environm & Hlth Interact, Leon, Spain

[10] Univ Leon, Fac Hlth Sci, Dept Biomed Sci, Area Prevent Med & Publ Hlth, Leon, Spain

[11] Univ Cantabria IDIVAL, Sch Med, Div Epidemiol & Computat Biol, Santander, Spain

[12] Inst Invest Biosanitaria Granada, Granada Hlth Res Inst ibs GRANADA, Granada, Spain

[13] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain

[14] Inst Salud Publ Navarra, IdiSNA Navarra Inst Hlth Res, Pamplona, Spain

[15] Univ Oviedo, Oncol Inst, Dept Med, Mol Epidemiol Canc Unit, Oviedo, Spain

[16] Donostia Univ Hosp, Dept Pathol, Donostia San Sebastian, Spain

[17] Fdn Promot Hlth & Biomed Res Valencia Reg FISABIO, Fdn La Fomento Invest Sanitaria & Biomed Comunita, Valencia, Spain

[18] Huelva Univ, Hosp Complex, Dept Gen Surg, Coloproctol Unit, Huelva, Spain

[19] IMIB Arrixaca, Reg Hlth Council, Dept Epidemiol, Murcia, Spain

[20] Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain

[21] Univ Leon, Dept Gastroenterol & Hepatol Complejo Asis, Leon, Spain

[22] Hosp Clin Barcelona, Gastroenterol Dept, Barcelona, Spain

[23] Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain

[24] CIBER Enfermed Hepat & Digestivas CIBEREHD, CIBER Liver & Digest Dis, Madrid, Spain

[25] Univ Barcelona, Dept Gastroenterol, Barcelona, Spain

[26] ISGlobal, Ctr Res Environm Epidemiol CREAL, Barcelona, Spain

[27] Hosp Mar, Med Res Inst IMIM, Barcelona, Spain

[28] Univ Pompeu Fabra, Dept Expt & Hlth Sci, Barcelona, Spain

[29] Hosp Llobregat, Catalan Inst Oncol IDIBELL, Canc Epidemiol & Res Program, Barcelona, Spain

[30] Red Espanola Invest Patol Infecciosa, Spanish Network Res Infect Dis, Seville, Spain

来源：

FRONTIERS IN MICROBIOLOGY | 2017年 / 8卷

关键词：

Helicobacter pylori; multiplex serology; colorectal neoplasm; chronic infection; bacterial infections; non-infectious diseases; GASTRIC-CANCER; COLON NEOPLASIA; INFECTION; ASSOCIATION; METAANALYSIS; CARCINOMA;

D O I：

10.3389/fmicb.2017.00888

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain. Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2,140 histologically-confirmed incident CRC cases and 4,098 population-based controls were recruited. Controls were frequency-matched by sex, age, and province. Epidemiological data were collected through a questionnaire fulfilled by face-to-face interviews and a self-administered food-frequency questionnaire. Seroreactivities against 16 H. pylori proteins were determined in 1,488 cases and 2,495 controls using H. pylori multiplex serology. H. pylori seropositivity was defined as positivity to >= 4 proteins. Multivariable logistic regression mixed models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results: H. pylori seropositivity was not associated with increased CRC risk (OR = 0.91; 95% CI: 0.71-1.16). Among H. pylori seropositive subjects, seropositivity to Cag delta showed a lower CRC risk, and risk decreased with increasing number of proteins seropositive. Seropositivity to the most recognized virulence factors, CagA and VacA, was not associated with a higher CRC risk. No statistically significant heterogeneity was identified among tumor sites, although inverse relations were stronger for left colon cancer. An interaction with age and sex was found: H. pylori seropositivity was associated with a lower CRC risk in men younger than 65 and with a higher risk in older women. Conclusions: Our results suggest that neither H. pylori seropositivity, nor seropositivity to the virulence factor CagA are associated with a higher CRC risk. A possible effect modification by age and sex was identified.

引用

页数：12

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