What is the ultimate goal in acid-base regulation?

被引：5

作者：

Balakrishnan, Selvakumar

Gopalakrishnan, Maya

Alagesan, Murali

Prakash, E. Sankaranarayanan

机构：

[1] Asian Inst Med Sci & Technol, Fac Med & Hlth Sci, Sch Med, Sungai Petani 08000, Kedah Darul Ama, Malaysia

[2] Jawaharlal Inst Postgrad Med Educ & Res, Dept Physiol, Pondicherry, India

来源：

ADVANCES IN PHYSIOLOGY EDUCATION | 2007年 / 31卷 / 01期

关键词：

acidosis; intracellular pH; homeostasis;

D O I：

10.1152/advan.00010.2006

中图分类号：

G40 [教育学];

学科分类号：

040101 ; 120403 ;

摘要：

It is common to see chapters on acid-base physiology state that the goal of acid-base regulatory mechanisms is to maintain the pH of arterial plasma and not arterial PCO2 (Pa-CO2) or plasma HCO3. A hypothetical situation in which the Pa-CO2 of arterial plasma is 80 mmHg and the plasma HCO3 concentration is 48 mM is presented and analyzed to get over this misconception. As per the modified Henderson equation, the pH of arterial plasma would be 7.4; however, we explain that this may be associated with intracellular acidosis due to intracellular hypercapnia and that derangement of homeostasis is evident from the occurrence of respiratory depression and, eventually, coma in the patient described. This suggests that the ultimate goal of acid-base regulatory mechanisms is not just the maintenance of the pH of arterial plasma but the maintenance of the steady-state pH of intracellular fluid as well.

引用

页码：51 / 54

页数：4