Binding of an inhibitor of the p53/MDM2 interaction to MDM2

被引：57

作者：

Duncan, SJ ^{[1
]}

Cooper, MA ^{[1
]}

Williams, DH ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

来源：

CHEMICAL COMMUNICATIONS | 2003年 / 03期

关键词：

D O I：

10.1039/b211889k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The mode of action of the secondary metabolite chlorofusin, which antagonises the interaction between p53 and MDM2, involves direct binding to the N-terminal domain of MDM2.

引用

页码：316 / 317

页数：2

共 10 条

[1] On the interaction between p53 and MDM2: Transfer NOE study of a p53-derived peptide ligated to MDM2 [J].

Blommers, MJJ ;

Fendrich, G ;

GarciaEcheverria, C ;

Chene, P .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (14) :3425-3426

[2]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[3] Bacillus thuringiensis Cry1Ac toxin interaction with Manduca sexta aminopeptidase N in a model membrane environment [J].

Cooper, MA ;

Carroll, J ;

Travis, ER ;

Williams, DH ;

Ellar, DJ .

BIOCHEMICAL JOURNAL, 1998, 333 :677-683

[4] Isolation and structure elucidation of chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp. [J].

Duncan, SJ ;

Grüschow, S ;

Williams, DH ;

McNicholas, C ;

Purewal, R ;

Hajek, M ;

Gerlitz, M ;

Martin, S ;

Wrigley, SK ;

Moore, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (04) :554-560

[5] Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain [J].

Kussie, PH ;

Gorina, S ;

Marechal, V ;

Elenbaas, B ;

Moreau, J ;

Levine, AJ ;

Pavletich, NP .

SCIENCE, 1996, 274 (5289) :948-953

[6] THE P53 TUMOR SUPPRESSOR GENE [J].

LEVINE, AJ ;

MOMAND, J ;

FINLAY, CA .

NATURE, 1991, 351 (6326) :453-456

[7] Analysis by surface plasmon resonance of the influence of valence on the ligand binding affinity and kinetics of an anti-carbohydrate antibody [J].

MacKenzie, CR ;

Hirama, T ;

Deng, SJ ;

Bundle, DR ;

Narang, SA ;

Young, NM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (03) :1527-1533

[8] THE MDM-2 ONCOGENE PRODUCT FORMS A COMPLEX WITH THE P53 PROTEIN AND INHIBITS P53-MEDIATED TRANSACTIVATION [J].

MOMAND, J ;

ZAMBETTI, GP ;

OLSON, DC ;

GEORGE, D ;

LEVINE, AJ .

CELL, 1992, 69 (07) :1237-1245

[9] ONCOPROTEIN MDM2 CONCEALS THE ACTIVATION DOMAIN OF TUMOR SUPPRESSOR-P53 [J].

OLINER, JD ;

PIETENPOL, JA ;

THIAGALINGAM, S ;

GVURIS, J ;

KINZLER, KW ;

VOGELSTEIN, B .

NATURE, 1993, 362 (6423) :857-860

[10] QUANTITATIVE-DETERMINATION OF SURFACE CONCENTRATION OF PROTEIN WITH SURFACE-PLASMON RESONANCE USING RADIOLABELED PROTEINS [J].

STENBERG, E ;

PERSSON, B ;

ROOS, H ;

URBANICZKY, C .

JOURNAL OF COLLOID AND INTERFACE SCIENCE, 1991, 143 (02) :513-526

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