Iron-Catalyzed α-Alkylation of Ketones with Alcohols

被引：249
作者：
Elangovan, Saravanakumar [1 ,2 ]
Sortais, Jean-Baptiste [1 ]
Beller, Matthias [2 ]
Darcel, Christophe [1 ]
机构：
[1] Univ Rennes 1, UMR CNRS 6226, Inst Sci Chim Rennes, Ctr Catalysis & Green Chem,Team Organometall Mat, F-35042 Rennes, France
[2] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 48期
关键词：
alkylation; borrowing hydrogen; homogeneous catalysis; Friedlander reaction; iron catalysts; CHIRAL BRONSTED ACID; COOPERATIVE TRANSITION-METAL; OPPENAUER-TYPE OXIDATION; BASE-MEDIATED SYNTHESIS; BORROWING HYDROGEN; ENANTIOSELECTIVE HYDROGENATION; REDUCTIVE AMINATION; COMPLEXES SYNTHESIS; SECONDARY ALCOHOLS; BOND FORMATION;
D O I：
10.1002/anie.201506698
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A general and benign iron-catalyzed alpha-alkylation reaction of ketones with primary alcohols has been developed. The key to success of the reaction is the use of a Knolker-type complex as catalyst (2 mol%) in the presence of Cs2CO3 as base (10 mol%) under hydrogen-borrowing conditions. Using 2-aminobenzyl alcohol as alkylation reagent allows for the "green" synthesis of quinoline derivatives.
引用
收藏
页码：14483 / 14486
页数：4
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