Photonic explorers based on multifunctional nanoplatforms for biosensing and photodynamic therapy

被引：56
作者：
Koo, Yong-Eun Lee [1 ]
Fan, Wenzhe
Hah, Hoejin
Xu, Hao
Orringer, Dan
Ross, Brian
Rehemtulla, Alnawaz
Philbert, Martin A.
Kopelman, Raoul
机构：
[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Environm Hlth Sci, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA
[5] Univ Michigan, Dept Radiat Oncol, Ann Arbor, MI 48109 USA
来源：
APPLIED OPTICS | 2007年 / 46卷 / 10期
关键词：
D O I：
10.1364/AO.46.001924
中图分类号：
O43 [光学];
学科分类号：
070207 ; 0803 ;
摘要：
Nanoparticle-based photonic explorers have been developed for intracellular sensing and photodynamic therapy (PDT). The design employs nanoparticles made of various matrices as multifunctional nanoplatforms, loading active components by encapsulation or covalent attachment. The nanoplatform for biosensing has been successfully applied to intracellular measurements of important ionic and molecular species. The nanoplatform for PDT has shown high therapeutic efficacy in a rat 9L gliosarcoma model. Specifically, a multifunctional nanoplatform that encompasses magnetic resonance imaging (MRI) and PDT agents inside, as well as targeting ligands on the surface, has been developed and applied in vivo, resulting in much improved MRI contrast enhancement and PDT efficacy. (c) 2007 Optical Society of America.
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收藏
页码：1924 / 1930
页数：7
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