UPLC-MS/MS and Dushman reaction based spectrophotometric method for determination of Ceftazidime, an antibiotic, in medicinal formulation

被引：4
作者：
Siddiqui, Masoom Raza [1 ]
Hakami, Afnan Ali Hussain [1 ,2 ]
Wabaidur, Saikh Mohammad [1 ]
Alothman, Zeid Abdullah [1 ]
Khan, Moonis Ali [1 ]
Husain, Fohad Mabood [3 ]
机构：
[1] King Saud Univ, Coll Sci, Chem Dept, Riyadh, Saudi Arabia
[2] Jazan Univ, Fac Sci, Chem Dept, Jazan, Saudi Arabia
[3] King Saud Univ, Coll Food & Agr Sci, Dept Food Sci & Nutr, Riyadh, Saudi Arabia
来源：
FOOD SCIENCE AND TECHNOLOGY | 2021年 / 41卷 / 01期
关键词：
Ceftazidime; UPLC-MS/MS; method development; spectrophotometry;
D O I：
10.1590/fst.07020
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Two analytical methods were developed, one utilizing sensitive UPLC-MS/MS method while other being the spectrophotometric method exploiting the Dushman reaction. Both methods were validated based on ICH guidelines and were successfully applied to quantitate the drug in marketed formulation. UPLC-MS/MS method responded linearly in the range of 1.6 mu gmL(-1)-6.4 mu gmL(-1) while spectrophotometric procedure followed the Beer's law in the concentration range of 30-100 mu gmL(-1). UPLC-MS/MS has been found to have a limit of quantitation of 0.971 mu gmL(-1) while spectrophotometric method was found to quantitate 14.00 mu gmL(-1) correctly with high precision. Both the methods showed an excellent recovery of 99.36%-100.91% (% RSD 1.05-1.73) and 98.64%-99.73% (%RSD 0.67-1.68) for UPLC-MS/MS and spectrophotometric, respectively.
引用
收藏
页码：225 / 231
页数：7
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